Giving to someone life is a blissful act, which assumed that except God no one can else do but little process of medical science has made a small step in this by transplanting the donor's organ or tissue to recipient person. This transplantation gives new life to needy person. But the most common challenge faced in this process is identifying and getting consent from donors. I thought to take it up as a new investigated area to identify the nurse's attitude, their understanding and what are they practicing in this area. This was a narrative review, here I have gathered information in a very systematic way. The electronic data base such as ProQuest, Embase, PubMed, PsycARTICLES, EBSCO, Research Gate, EORTC, Scopus, Educational Resources Information Centre (ERIC), and Allied Health Literature (CINHAL) were searched and article published in between from 2012 to 2022 were identified. A total 878 articles were received from these search engines and based on systematic scrutinizing process a total of 10 articles were included in the review. Reviewed study's findings suggested that nurses are carrying limited knowledge with some constrained attitude and with poorly practicing it in their professional life, therefore researcher recommends to take up such problem and introduce intervention to enhance the overall understanding, attitude and practice of staff nurses who are working in real clinical set-up.