Field surveys and radiocarbon dating of detrital materials provide evidence that repeated landslides dammed the Yigong Tsangpo River ca. 3500 bc, 1300 bc, 1000 bc, 600 bc, and twice more recently. Together with historical slides in 1900 and 2000, these six older slides make for a total of eight known channel-damming landslide events at the same location over the past six millennia, indicating submillennia recurrence intervals over this time period. Together with the likely incomplete nature of the sedimentary record of past channel-damming episodes uncovered to date, our findings indicate late Holocene multi-century-scale recurrence intervals for large landslides at this location. Hence, the riverbed at and immediately upstream of this location may have been inundated by sediment, and therefore not incising, for much of the post-glacial period. Together with the location of this landslide complex at the head of the major knickzone defining the fluvial edge of the Tibetan Plateau, our findings support the hypothesis that repeated glacial and landslide damming in this region inhibited headward propagation of river incision into the Tibetan Plateau. Landslides can be important erosional processes in upland landscapes with moderate to steep hillslopes 1. In particular, landsliding dominates hillslope erosion in rapidly uplifting terrain where high-relief, threshold hillslopes, and relatively narrow river gorges are common 1-5. Landslides can introduce large amounts of sediment into river systems and large landslides can dam channels, impounding water and sediment 6,7. In turn, an elevated sediment supply can retard river incision by shielding bedrock 8. Korup and Montgomery proposed that frequent glacial damming in the eastern Himalayan syntaxis (EHS) during the Quaternary inhibited headward incision of major rivers, thereby retarding dissection into the edge of the Tibetan Plateau 2. While this hypothesis was rooted in evidence for repeated glacial damming of the Yarlung Tsangpo immediately above its gorge through the Himalaya 9 , similar glacial and landslide blockages occur on other major tributaries upstream of the deeply incised bedrock gorges in the EHS 2. Little is known, however, about the frequency with which channel damming events have occurred in the region. The Lulang landslide-dammed lake in the upper reaches of the Lulang River, a tributary to the Parlung Tsangpo, was reported recently to have remained stable from before 24.2 ka bp to around 8.8 ka bp 10. This period extends roughly through the last glacial maximum and well into the early Holocene. Like the glacial dam on the Yarlung Tsangpo, the Lulang landslide sits just upstream of the headward extent of the knickzone upstream of the deeply incised-trans-Himalayan bedrock gorge 10. In April, 2000, the giant Yigong landslide dammed the Yigong Tsangpo River with 3 × 10 8 m 3 of sediment that formed a 60 m high dam 11. Subsequent failure of the dam sent floodwaters rushing down through the gorge, causing extensive damage for 500 km downstream into India...