How accurately can QT interval be measured in newborn infants?

Groote, Katya De; Suys, Bert; Deleeck, An; Wolf, Daniël De; Matthys, Dirk; Overmeire, Bart Van

doi:10.1007/s00431-003-1321-9

Cited by 17 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, four infants in the methadone group had a QTc≥500 ms. One of these infants had a heart rate of 88/min, but the infant was otherwise asymptomatic. The interobserver and intraobserver agreement reported in the study is acceptable for QTc intervals in infants and compares favourably with previous reported intraobserver variability for cardiologists 18. In this study, surprisingly, there was no correlation between maternal methadone dosage and prolongation of QTc.…”

Section: Discussionsupporting

confidence: 86%

Maternal methadone therapy increases QTc interval in newborn infants

Parikh

Hussain

Holder

et al. 2010

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 86%

Maternal methadone therapy increases QTc interval in newborn infants

Parikh

Hussain

Holder

et al. 2010

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

show abstract

“…These investigations are widely practiced in the treatment of adults. The ECG, a determining factor in the diagnosis of hypoxic-ischemic cardiac insult in adults, is of less value in neonatal practice [11,12] . The small diameter of the chest in relation to the size of the electrodes and infant activity could make the examination useless.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Cardiac Troponin T and Echocardiography in the Diagnosis of Hypoxic Myocardial Injury of Full-Term Neonates

Szymankiewicz

Matuszczak-Wleklak²,

Hodgman³

et al. 2005

Neonatology

View full text Add to dashboard Cite

Background: Perinatal asphyxia constitutes a significant problem influencing neonatal mortality and morbidity. Objectives: The aim of the present work was to provide evidence of the usefulness of cardiac troponin T (cTnT) and echocardiographic investigations in the diagnosis of heart damage in full-term infants after intrauterine hypoxia. Material and Methods: The subjects were 39 asphyxiated and 44 term infants without fetal anoxia. Quantitative determinations of cTnT were performed between 12 and 24 h of life. Two-dimensional Doppler and color Doppler studies were performed at the bedside. We evaluated fractional shortening (FS), cardiac output (CO), cardiac index (CI), tricuspid (TI) and mitral (MI) insufficiency. Results: Asphyxiated infants presented increased cTnT (mean 0.141 ± 0.226 vs. 0.087 ± 0.111ng/ml; p < 0.01) and TI (38.5 vs. 11.4% of population; p < 0.05) compared to healthy infants. CO, CI and FS remained in the same range. Conclusions: We found cTnT to be the most useful among accessible diagnostic tools used in post-hypoxic heart damage in neonates. The data from our relatively small population study suggest a cTnT value of >0.1 ng/ml as a reliable marker of myocardial injury in neonates. Further study should be performed to generate a receiver-operator characteristic curve to discover what the cut-off level should be.

show abstract

“…One study of 53 ECG recordings from neonates showed large inter-observer and intra-observer differences. 15 Therefore, in our case, T-wave measurements were conducted in several beats, and the interpretation was confirmed by a paediatric cardiologist.…”

Section: Discussionmentioning

confidence: 79%

Prolonged QT interval in an infant of a fluoxetine treated mother

Dubnov

Fogelman

Merlob

2005

Archives of Disease in Childhood

View full text Add to dashboard Cite

Fluoxetine is an antidepressant drug, only recently discovered to be a QT interval prolonging agent. The first case is presented of an infant of a mother treated with fluoxetine during pregnancy who had a transiently prolonged QTc interval, concluded to be drug induced. Clinical and electrocardiographic monitoring of newborns of antidepressant treated mothers is needed. F luoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly used for the treatment of depression. SSRIs have been found to be superior to the traditional tricyclic antidepressants because of their lower profile of adverse effects. These findings may extend also to newborns of treated mothers.1 Fluoxetine was originally considered to have no electrocardiographic effects. Several recent publications, however, have associated fluoxetine with QT prolongation. [2][3][4][5] We describe the first case of a newborn of a mother treated with fluoxetine throughout pregnancy with a prolonged corrected QT interval (QTc) on the initial routine electrocardiogram (ECG). CASE REPORTA male infant was born after 40 weeks' gestation to a 41 year old mother, gravida 3, para 1, abortus 2 (one spontaneous, one induced), who had been treated throughout pregnancy with fluoxetine, 30 mg daily, for depression, and Eltroxin for hypothyroidism. The pregnancy was uncomplicated, with normal triple test, amniocentesis, and fetal ultrasound results. Birth was vacuum assisted, Apgar score was normal. Umbilical cord blood gas levels were within normal range.Birth weight was 2975 g, length 50 cm, head circumference 34.5 cm-all appropriate for gestational age. Physical examination revealed a well appearing infant; a mild 1/6 systolic murmur at the lower left sternal border was the only clinical finding. The infant was placed in a clear incubator with a cardiorespiratory monitor to screen for SSRI withdrawal symptoms using the Finnegan Neonatal Abstinence Scoring System. Blood tests were performed in accordance with our departmental protocol for all infants born to SSRI treated mothers. Blood chemistry values at age 24 hours were within normal range: sodium 141 mEq/l, potassium 5.7 mEq/l, chloride 108 mEq/l, creatinine 1.0 mg/dl, urea 32 mg/dl, calcium 9.7 mg/dl, phosphorus 6.2 mg/dl. Liver enzyme levels, coagulation function tests, and a complete blood count were normal. A routine electrocardiogram (ECG) was performed at around 30 hours of age (fig 1). Analysis revealed a QRS rate of 120 and sinus rhythm, axis of 110 degrees, and normal P wave, QRS complex, and ST segment morphology. PR interval was 0.08 seconds, QRS duration was 0.06 seconds, and QTc interval, as determined by Bazett's formula, was 0.54-0.58 seconds. An echocardiogram was completely normal. The ECG was repeated on the following days and showed a decline in interval to 0.38-0.36 seconds.The hospitalisation course was uneventful. At the age of 2 months, a repeated ECG performed by the child's physician was reported to have a QTc of 0.42 seconds. On follow up at age 4 months, the infant's mother reported n...

show abstract

How accurately can QT interval be measured in newborn infants?

Cited by 17 publications

References 21 publications

Maternal methadone therapy increases QTc interval in newborn infants

Maternal methadone therapy increases QTc interval in newborn infants

Usefulness of Cardiac Troponin T and Echocardiography in the Diagnosis of Hypoxic Myocardial Injury of Full-Term Neonates

Prolonged QT interval in an infant of a fluoxetine treated mother

Contact Info

Product

Resources

About