How Ancestral Trauma Informs Patients' Health Decision Making

Sacks, Tina K.; Savin, Katie; Walton, Quenette L.

doi:10.1001/amajethics.2021.183

Cited by 12 publications

(2 citation statements)

References 16 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Trials that report race and ethnicity may have a greater focus on enrolling these populations. This higher rate of enrollment occurred despite prior evidence suggesting that caregivers of Black/African American children may have distrust of medical research because of the historical and current racism exhibited in medicine in the US . This finding aligns with those of the 2003 analysis of pediatric studies but differs from disease-specific studies assessing pediatric participant enrollment .…”

Section: Discussionmentioning

confidence: 47%

Reporting of Participant Race and Ethnicity in Published US Pediatric Clinical Trials From 2011 to 2020

et al. 2022

View full text Add to dashboard Cite

of participants who are members of racial and ethnic minority groups in clinical trials enhances inclusivity in the scientific process and generalizability of results.OBJECTIVE To assess participant race and ethnicity in pediatric clinical trials published from 2011 to 2020. DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional study examined articles reporting pediatric clinical trials conducted in the US published in 5 leading general pediatric and 5 leading general medical journals from January 1, 2011, to December 31, 2020. MAIN OUTCOMES AND MEASURESReporting of participant race and ethnicity and comparison of enrolled participants vs US census populations of pediatric racial and ethnic groups in published clinical trials. RESULTSThe study included 612 articles reporting pediatric clinical trials during the study period, with 565 618 total participants (median per trial, 200 participants [IQR, 90-571 participants]). Of the 612 articles, 486 (79.4%) reported participant race and 338 (55.2%) reported participant ethnicity. From 2011 to 2020, relative rates of reporting of participant race increased by 7.9% per year (95% CI, 0.2%-16.3% per year) and reporting of ethnicity increased by 11.4% per year (95% CI, 4.8%-18.4% per year). Among articles reporting race and ethnicity, the method of assignment was not reported in 261 of 511 articles (51.1%) and 207 of 359 articles (57.7%), respectively. Black/African American children were enrolled proportionally more than the US population of Black/African American children (odds ratio [OR], 1.88; 95% CI, 1.87-1.89). Hispanic/Latino children were enrolled commensurately with the US population of Hispanic/Latino children (OR, 1.02; 95% CI, 1.01-1.03). American Indian/Alaska Native (OR, 0.82; 95% CI, 0.79-0.85), Asian (OR, 0.56; 95% CI, 0.55-0.57), and Native Hawaiian/Pacific Islander (OR, 0.66; 95% CI, 0.61-0.72) children were enrolled significantly less compared with the respective US populations of these groups. White children were enrolled less than expected (OR, 0.84; 95% CI, 0.84-0.85) but represented 188 156 (46.0%) of participants in trials reporting race or ethnicity. CONCLUSIONS AND RELEVANCEThis cross-sectional study revealed that the proportion of published pediatric clinical trials that reported participant race and ethnicity increased from 2011 to 2020, but participant race and ethnicity were still underreported. Disparities existed in pediatric clinical trial enrollment of American Indian/Alaska Native, Asian, and Native Hawaiian/Pacific Islander children. The greater representation of Black/African American children compared with the US population suggests inclusive research practices that could be extended to other historically disenfranchised racial and ethnic groups.

show abstract

Section: Discussionmentioning

confidence: 47%

Reporting of Participant Race and Ethnicity in Published US Pediatric Clinical Trials From 2011 to 2020

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Previous studies also indicate that Black youths’ mental health is related to the structural violence, systemic racism, and trauma they may regularly experience ( Bath and Njoroge 2021 ; Meza and Bath 2021 ; Sheftall and Miller 2021 ; Voisin 2019 ). Furthermore, some scholars note that historical or ancestral trauma continues to impact the health, mental health, and healthcare decision-making of populations of color ( Dorsey 2020 ; Quinn 2018 ; Sacks et al 2021 ). Given that, we contend that Hypothesis 1 was partially supported.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Religion, Substance Misuse, and Mental Health among Black Youth

et al. 2023

View full text Add to dashboard Cite

Studies suggest that religion is a protective factor for substance misuse and mental health concerns among Black/African American youth despite reported declines in their religious involvement. However, few studies have investigated the associations among religion, substance misuse, and mental health among Black youth. Informed by Critical Race Theory, we evaluated the correlations between gender, depression, substance misuse, and unprotected sex on mental health. Using multiple linear regression, we assessed self-reported measures of drug use and sex, condom use, belief in God, and religiosity on mental health among a sample of Black youth (N = 638) living in a large midwestern city. Results indicated drug use, and sex while on drugs and alcohol, were significant and positively associated with mental health symptoms. Belief in God was negatively associated with having sex while on drugs and alcohol. The study’s findings suggest that despite the many structural inequalities that Black youth face, religion continues to be protective for Black youth against a myriad of prevalent problem behaviors.

show abstract

The Inclusion of Racial and Ethnic Minority Groups in Clinical Trials

Williams

2023

The International Library of Bioethics

View full text Add to dashboard Cite

How Ancestral Trauma Informs Patients' Health Decision Making

Cited by 12 publications

References 16 publications

Reporting of Participant Race and Ethnicity in Published US Pediatric Clinical Trials From 2011 to 2020

Reporting of Participant Race and Ethnicity in Published US Pediatric Clinical Trials From 2011 to 2020

The Relationship between Religion, Substance Misuse, and Mental Health among Black Youth

The Inclusion of Racial and Ethnic Minority Groups in Clinical Trials

Contact Info

Product

Resources

About