How are maternal dietary patterns and maternal/fetal cytokines associated with birth weight? A path analysis

Ma, Ligeng; Lu, Qinggui; Ouyang, Jingyi; Huang, Jie; Huang, Shaoming; Jiao, Changya; Zhang, Zheqing; Mao, Limei

doi:10.1017/s0007114519000382

Cited by 14 publications

(9 citation statements)

References 45 publications

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“…Hence, the biological intrauterine component is likely to change maternal physiology in favour of later‐borns and needs to be further investigated with regard to sibling pregnancies. Differences in the rate of foetal weight gain throughout pregnancy, 23 the overall quality of life of the mother during pregnancy, 24 maternal dietary patterns 25 as well as the maternal nutritional supply and with it the glucose‐ and lipid metabolism 26 could be promising approaches. Those factors may not only affect growth and weight of the foetus directly by biological mechanisms, but also through epigenetic modifications.…”

Section: Discussionmentioning

confidence: 99%

Birth weight increases with birth order despite decreasing maternal pregnancy weight gain

et al. 2020

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Aim We investigated whether birth order is an influencing factor for birth weight independent from maternal factors. Methods Data were obtained from the longitudinal cohort study LIFE Child and included 1864 children, of which 526 were only children. The 1338 siblings were ranked into first‐borns (n = 570), second‐borns (n = 606) and third‐or‐later‐borns (n = 162). Children born prematurely, suffering from chronic or syndromic diseases, were excluded. We performed intra‐family comparisons to reduce bias and assessed the impact of perinatal parameters, such as birth order on birth weight, using mixed models. Results Birth weight increased with birth order. In univariate analyses, birth order had a significant effect on birth weight‐SDS with second‐borns having 0.29 SDS (app. 130 g) and third‐borns 0.40 SDS (app. 180 g) higher values than first‐borns (P < .001). Maternal pregnancy weight gain was associated with higher birth weight‐SDS (P < .01) in univariate analysis, though maternal pregnancy weight gain was lower for higher birth orders. Multivariate analyses revealed that being a second or third‐or‐later‐born child had a stronger impact on birth weight than all maternal factors. Conclusion Birth order must be considered a potential risk factor for higher birth weight. Maternal pregnancy weight gain is not the driving factor for higher birth weight in siblings.

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Section: Discussionmentioning

confidence: 99%

Birth weight increases with birth order despite decreasing maternal pregnancy weight gain

et al. 2020

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“…State anxiety refers to the temporary restlessness caused by a speci c situation [9] .Trait anxiety refers to a general personality characteristic or trait, which is manifested as a kind of more or less continuous worry and uneasiness [10] .ST-AI [11] has 40 questions that can well measure the state anxiety and trait anxiety.FAD-18 [12] with 18 questions measures family function from the four dimensions of cohesion, behavior control, growth and adaptability, and is a mature scale designed for China. Path analysis is a widely used method to analyze the causal relationship between variables and proved to be a very effective analysis method [13] . Thus, this study used path analysis in structural equation model (SEM)to determine the relationship of family function, state anxiety and trait anxiety.ST-AI scale and FAD-18 scaleare used to evaluate family functions, state anxiety and trait anxiety of Chinese college students.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Family Function on State and Trait Anxiety of Chinese College Students During the Epidemic of COVID-19

Yang

Wang

et al. 2020

Preprint

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BACKGROUND: COVID-19 has a terrible impact worldwide, and more than 0.8 million people had died of it before September 2020. Many countries had taken many measures to against it, and one of the most effective methods was "stay-at-home" order. But staying at home for a long time is not good for human beings with social features, and that may lead to the occurrence of psychological diseases. Because of COVID-19, many people were forced to stay at home and spend more time with family members. As a special group of population, Chinese college student are more dependent on families, and their psychology, such as anxiety, may be more affected by family during the outbreak of COVID-19.METHODS: This cross-sectional study was conducted online from March 14, 2020 to March 21, 2020.The State-Trait Anxiety Inventory (ST-AI) and Chinese Family Function Scale (FAD-18) were used in this study. ANOVA was used in basic information. Path analysis was used to estimate the relationship among family function, state anxiety and trait anxiety.RESULTS: A total of 1039 respondents (695 females and 344 males) were included in the study. Their state anxiety scores were 39.28 and 36.84, respectively. The trait anxiety scores were 40.66 and 38.36, respectively. There were significant differences (p<0.01). But compared with the healthy norm, there was no significant difference. Except gender, there were significant differences (p<0.01) in state anxiety and trait anxiety between college students of medicine and art majors. In path analysis, the standard direct effect of family function on trait anxiety was 0.434(p< 0.001) in male group, 0.271(p< 0.001) in female group. While the standard direct and indirect effect of family function on state anxiety were not significant.CONCLUSIONS: This study found that during the outbreak of COVID-19, the state anxiety and trait anxiety of Chinese college students were related to gender and major. What’s more, family function had a great influence on anxiety. It is very important to pay attention to health function of family and psychological counseling for different genders and majors.

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“…If our findings are confirmed, there is a potential to improve children's respiratory function and reduce their risk for wheeze by intervening on potential modifiable factors of adiponectin and leptin concentrations, including maternal diet. 54,55 Supplementary materials. For supplementary material for this article, please visit https://doi.org/10.1017/S2040174420000951 Financial Support.…”

Section: Discussionmentioning

confidence: 99%

Does fetal leptin and adiponectin influence children’s lung function and risk of wheeze?

Jackson-Browne

et al. 2020

J Dev Orig Health Dis

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Adipocytokines, which are secreted during fetal development by both mothers and fetuses, may influence fetal lung development, but little human data are available. We used data from the HOME Study to investigate the associations of cord blood adipocytokine concentrations with children’s lung forced expiratory volume (FEV1; N = 160) and their risk of wheeze (N = 281). We measured umbilical cord serum adipocytokine concentrations using enzyme-linked immunosorbent assays and FEV1 using a portable spirometer at ages 4 and 5 to calculate the percent predicted FEV1 (%FEV1). Parents completed standardized questionnaires of their child’s wheeze symptoms every 6 months from birth to age 5, then again at ages 6 and 8. We used multivariable linear mixed models and modified Poisson regression with generalized estimating equations to estimate associations of adipocytokine concentrations (log2-transformed) with children’s %FEV1 and the risk of wheeze, respectively, adjusting for sociodemographic, perinatal, and child factors. Cord serum leptin was not associated with children’s %FEV1. Higher cord serum adiponectin concentrations were associated with higher %FEV1 in girls (β = 3.1, 95% confidence interval [CI]: 0.6, 5.6), but not in boys (β = −1.3, 95% CI: −5.9, 3.3) (sex × adiponectin p-value = 0.05). Higher leptin was associated with lower risk of wheeze in girls (RR = 0.74, 95% CI: 0.66, 0.84), but not boys (RR = 0.87, 95% CI: 0.69, 1.11) (sex × leptin p-value = 0.01). In contrast, higher adiponectin concentrations were associated with lower risk of wheeze (RR = 0.84, 95% CI: 0.73, 0.96) in both boys and girls. These data suggest that fetal adipocytokines may impact lung development and function in early childhood. Future studies are needed to confirm these findings and explore the mechanisms underlying these associations.

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How are maternal dietary patterns and maternal/fetal cytokines associated with birth weight? A path analysis

Cited by 14 publications

References 45 publications

Birth weight increases with birth order despite decreasing maternal pregnancy weight gain

Birth weight increases with birth order despite decreasing maternal pregnancy weight gain

The Influence of Family Function on State and Trait Anxiety of Chinese College Students During the Epidemic of COVID-19

Does fetal leptin and adiponectin influence children’s lung function and risk of wheeze?

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