How asymptomatic are early cancer patients of five organs based on registry data in Japan

Abstract

Cancer registry data indicate that early cancers are asymptomatic, and once symptoms appear, treatment may not be effective. Policy makers should inform people of the necessity of cancer screening before they have symptoms.

Computational modeling of locoregional recurrence with spatial structure identifies tissue-specific carcinogenic profiles

“…We have specified the growth rate for each cancer using the r S values from our clinical fitting. Interestingly, we observed relatively high growth rates of malignant cells (Type S cells) in some common cancer types like lung and colorectal cancers, whereas a relatively lower growth rate was estimated in breast invasive carcinoma which was also a common cancer type but was relatively asymptomatic in agreement with several studies (46,47). From the high m S-1 values, we elucidated that uveal melanoma, breast invasive carcinoma, stomach adenocarcinoma and lung squamous cell carcinoma had the shortest time to reach late premalignant cell stage from the earliest premalignant cell stage possibly indicating fewer mutational steps.…”

Impact of coronavirus disease 2019 on the number of newly diagnosed cancer patients and examinations and surgeries performed for cancer in Japan: a nationwide study

“…Substantial variation was observed across cancer types and stages of cancer. Regarding stage I gastric cancer, the number of cases decreased by 30.9% (25 vs. 15 [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], p < 0.001). In Q3 and Q4, the reduction was…”

“…The reduction in surgeries for gastric cancer was 25.5% (16 [8-25] vs. 12 [6. [5][6][7][8][9][10][11][12][13][14][15][16][17][18], p < 0.001) in Q3, followed by 15.2% (16 [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] vs. 14 [8-20.5], p < 0.001) in Q4, and 14.3% (13 [8-21.5] vs. 12 [7-18.5], p = 0.003) in Q2. The number of gastric cancer cases treated using endoscopic procedures decreased by 19.7% (16 [8-27] vs. 13 [7-22.5], p < 0.001) in Q2 and 19.4% (16 [9.5-25.5] vs. 15 [7][8][9][10][11][12][13][14][15][16][17][18][19][20]…”

“…The reduction was significant in the early stages of gastric, colorectal, and breast cancer but not in lung and cervical cancer. Based on the study in Japan, the proportion of asymptomatic cases in stage I was reported to be high, of which 59.4% for gastric, 55.5% for colorectal, 78.9% for lung, 39.8% for breast, and 48.6% for cervical cancer [16]. In Austria, there were more symptomatic cases of newly diagnosed breast cancer during the pandemic than pre-pandemic period [17].…”

Lesiones premalignas y malignas del estómago en pacientes sin tamización para cáncer gástrico

“…En el estadio I del CG, cerca del 60 % de los pacientes pueden ser asintomáticos, mientras que en los estadios II y III el 26 % y el 21 % también pueden serlo. Incluso el 10 % de los pacientes con estadio IV pueden presentarse sin síntomas, limitando el diagnóstico y una atención adecuada 5 .…”