How Benign Is IgA Nephropathy with Minimal Proteinuria?

Freda, Benjamin J.; Braden, Gregory

doi:10.1681/asn.2012080862

Cited by 6 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study aims to assist assessment of the appropriateness of the current recruitment policy in relation to those applicants with evidence of renal disease. Previously unpublished analysis of incidence of newly diagnosed glomerulonephritis following enlistment or commissioning in one Indo-Asian group that traditionally applies for service in the British army revealed that it was fourfold that of Caucasian service personnel, an observation congruent with evidence reviewed in oriental populations 9. The nature of the renal disease (IgA vs non-IgA nephropathy) was not statistically different from that of Caucasians in the military group, an observation also confirmed by others in civilians.…”

Section: Introductionsupporting

confidence: 62%

Review of cases of IgA nephropathy

World

2013

J R Army Med Corps

View full text Add to dashboard Cite

The proportion of military cases of IgA nephropathy with deteriorating renal function (22%) was not different from that described in civilians, suggesting that military medical management (including operational restriction where necessary) was appropriate. Initial clinical observations, including racial group, did not permit confident prediction of prognosis thus mandating follow-up for all military cases. Relaxing current enlistment policy would be inadvisable given the inability to confidently predict prognosis in individual cases.

show abstract

Section: Introductionsupporting

confidence: 62%

Review of cases of IgA nephropathy

World

2013

J R Army Med Corps

View full text Add to dashboard Cite

show abstract

“…The two patients who did not undergo biopsy had the presumptive diagnosis of IgAN based on clinical presentation, as is common practice. 23 At the time of diagnosis 75% of the subjects had normal kidney function as defined by GFR, 62.5% had mild proteinuria (<1 g/day), and 100% had dysmorphic hematuria.…”

Section: Resultsmentioning

confidence: 99%

IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin–angiotensin system activity

Abdi-Ali

Mann

Hemmelgarn

et al. 2014

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Background: IgA nephropathy is associated with increased cardiovascular risk, though whether this is due to loss of kidney function or proteinuria is unclear. Methods: For this study 10 normotensive IgA nephropathy subjects with early kidney disease (41±5 yrs, glomerular filtration rate (GFR) 87±9 ml/min, proteinuria 720±300 mg/d) and 10 gender-and blood pressure-matched healthy controls (36±1 yrs, estimated GFR 102±5 ml/min, proteinuria 70±6 mg/d) were studied in high-salt balance. Blood pressure and arterial stiffness, expressed as pulse wave velocity and aortic augmentation index, were measured at baseline and in response to 60 min of angiotensin II (AngII) infusion. Results: At baseline, IgA nephropathy subjects demonstrated similar pulse wave velocity (8.6±0.7 vs. 8.0±0.4 m/s, p=0.5) but increased aortic augmentation index (12.6±3.1 vs. 1.8±4%, p=0.04) and a trend towards increased circulating renin-angiotensin system (RAS) components (plasma renin activity, 0.55±0.18 vs. 0.21±0.05 ng/l/s, p=0.08; angiotensin II, 25±5 vs. 16±1 ng/l, p=0.08) compared with controls. However, despite similar baseline blood pressure values (p=0.8), IgA nephropathy was associated with reduced arterial sensitivity to AngII challenge (Δmean arterial pressure: 19±4 vs. 29±1 mm Hg, p=0.05; Δpulse wave velocity: -0.06±0.6 vs. 1.5±0.3 m/s, p=0.07) compared with controls, even after multivariate analysis. Conclusion: Even in the setting of early kidney disease, IgA nephropathy is associated with increased arterial stiffness and decreased angiotensin II responsiveness, a marker of increased RAS activity.

show abstract

“…Its clinical features are highly variable, ranging from simple hematuria with or without proteinuria to a rapidly progressive loss of renal function. [ 3 ] Progression to end-stage renal disease (ESRD) occurs in 10–50% of patients, usually developing slowly over 20 years. [ 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

Long-term prognosis of IgA nephropathy presenting with minimal or no proteinuria: A single center experience

Imai¹,

Shirai²,

Yasuda³

et al. 2016

Indian J Nephrol

View full text Add to dashboard Cite

The long-term prognosis of patients with IgA nephropathy (IgAN) who present with preserved renal function and minimal proteinuria is not well described. We investigated the long-term outcomes of IgAN patients with an apparently benign presentation and evaluated prognostic factors for renal survival and clinical remission. We studied Japanese patients with biopsy-proven IgAN who had an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 and proteinuria <0.5 g/day at the time of renal biopsy. The renal biopsies were reviewed using the Oxford classification. Twenty patients met the inclusion criteria. At diagnosis, the median eGFR (interquartile range) was 76.8 (65.2–91.1) mL/min/1.73 m2, and the median proteinuria level was 0.31 (0.16–0.39) g/day. Only one patient had an increase in serum creatinine of over 50% and no patient progressed to end-stage renal disease. The 15-year renal survival rate was 93.8%. Clinical remission was observed in 9 (45%) patients. Baseline proteinuria was the only factor significantly associated with the absence of clinical remission. The long-term prognosis of Japanese patients with IgAN who presents with minor urinary abnormalities and preserved renal function is excellent.

show abstract

How Benign Is IgA Nephropathy with Minimal Proteinuria?

Cited by 6 publications

References 25 publications

Review of cases of IgA nephropathy

Review of cases of IgA nephropathy

IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin–angiotensin system activity

Long-term prognosis of IgA nephropathy presenting with minimal or no proteinuria: A single center experience

Contact Info

Product

Resources

About