Agile and Lean methodologies have transformed research and consulting practices, increasing efficiency, speed, and impact. However, successful implementation depends on a critical yet often overlooked factor: the human dimension. This chapter explores the importance of human factors in Agile and Lean transformations, drawing insights from compelling case studies. The analysis covers successful and unsuccessful implementations of Agile research sprints and Lean consulting. Successful cases demonstrate early consumer insights, rapid product iteration, enhanced team alignment in research (Case Study 1), streamlined operations, increased employee engagement, and a culture of continuous improvement in consulting (Case Study 2). Conversely, unsuccessful cases highlight the pitfalls of neglecting the human aspect. Forced Agile research led to data gaps, unclear findings, and researcher disengagement (Case Study 3), while resistance to Lean consulting resulted in stalled implementation, declining morale, and limited impact (Case Study 4). The chapter identifies key human factors crucial for successful Agile and Lean transformations by examining these contrasting outcomes. Optimising the human dimension is essential for unlocking the full potential of Agile and Lean methodologies. The chapter outlines future research directions, including understanding individual preferences, fostering team dynamics, measuring human impact, ensuring long-term sustainability, and adapting these methodologies to new research and consulting domains.