“…According to a 1998 review by Tsukamoto et al., only 23 cases of either PFO or ASD associated with an atrial have been reported in the English literature, with only 8 of these attributed to PFOs alone [9] . Since then, our literature review reveals 15 additional cases of an atrial myxoma with a PFO reported, to include our own [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] . In fact, some of these cases have demonstrated profound clinical effects, such as right-to-left shunting, hypoxemia, and even cryptogenic pulmonary emboli caused by tumor prolapse left-to-right through the PFO and subsequent immune and surface-mediated thrombogenesis [10] , [12] .…”