How can lessons from the COVID-19 pandemic enhance antimicrobial resistance surveillance and stewardship?

Walia, Kamini; Mendelson, Marc; Kang, Gagandeep; Ramasubramanian, V; Sinha, Rina; Vijay, Sonam; Veeraraghavan, Balaji; Basnyat, Buddha; Rodrigues, Camilla; Bansal, N.K.; Ray, Pallab; Mathur, Purva; Gopalakrishnan, Ram; Ohri, V C

doi:10.1016/s1473-3099(23)00124-x

Cited by 20 publications

(7 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antimicrobial resistance and the emergence of CR- K. pneumoniae strains represent a major problem in hospitals worldwide. The recent SARS-CoV-2 pandemic has placed an additional burden on healthcare facilities and their ability to control the spread of antimicrobial resistance [ 22 , 23 , 24 ]. In ICUs in particular, the risk of MDR infections increased consistently owing to the high number of invasive procedures, such as mechanical ventilation, and the use of central venous catheters [ 25 , 26 , 27 , 28 ] and because of the intensive use as well as the overuse of broad-spectrum antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Screening of Klebsiella pneumoniae subsp. pneumoniae Strains with Multi-Drug Resistance and Virulence Profiles Isolated from an Italian Hospital between 2020 and 2023

Dimartino,

Venditti,

Messina

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Klebsiella pneumoniae strains that are resistant to multiple drugs (KPMDRs), which are often acquired in hospital settings and lead to healthcare-associated infections, pose a serious public health threat, as does hypervirulent K. pneumoniae (hvKp), which can also cause serious infections in otherwise healthy individuals. The widespread and often unnecessary use of antibiotics seen during the recent COVID-19 pandemic has exacerbated the challenges posed by antibiotic resistance in clinical settings. There is growing concern that hypervirulent (hvKp) strains may acquire genes that confer antimicrobial resistance, thus combining an MDR profile with their increased ability to spread to multiple body sites, causing difficult-to-treat infections. This study aimed to compare resistance and virulence profiles in KPC-3-producing K. pneumoniae isolates collected over four years (2020–2023). A genome-based surveillance of all MDR CRE-K. pneumoniae was used to identify genetic differences and to characterize the virulence and resistance profiles. Our results provide a picture of the evolution of resistance and virulence genes and contribute to avoiding the possible spread of isolates with characteristics of multi-drug resistance and increased virulence, which are thought to be one of the main global challenges to public health, within our hospital.

show abstract

Section: Discussionmentioning

confidence: 99%

Screening of Klebsiella pneumoniae subsp. pneumoniae Strains with Multi-Drug Resistance and Virulence Profiles Isolated from an Italian Hospital between 2020 and 2023

Dimartino,

Venditti,

Messina

et al. 2024

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Most patients do not finish the prescribed antibiotic courses, unintentionally contributing to the emergence of resistance. In addition to using antibiotics for medicinal purposes, the agricultural sector has made contributions by stimulating the development and growth of animals and other non-therapeutic uses of antibiotics ( Dankar et al, 2022 ; Walia et al, 2023 ). The etiology of antibiotic resistance is developed by multiple factors, each having their additional role.…”

Section: Driving Factors For Antibiotic Resistancementioning

confidence: 99%

Extensively and multidrug-resistant bacterial strains: case studies of antibiotics resistance

Almutairy

2024

Front. Microbiol.

View full text Add to dashboard Cite

The development of antibiotic resistance compromises the effectiveness of our most effective defenses against bacterial infections, presenting a threat to global health. To date, a large number of research articles exist in the literature describing the case reports associated with extensively drug-resistant (XDR) and multidrug-resistant (MDR) bacterial strains. However, these findings are scattered, making it time-consuming for researchers to locate promising results and there remains a need for a comparative study to compile these case reports from various geographical regions including the Kingdom of Saudi Arabia. Additionally, no study has yet been published that compares the genetic variations and case reports of MDR and XDR strains identified from Saudi Arabia, the Middle East, Central Europe, and Asian countries. This study attempts to provide a comparative analysis of several MDR and XDR case reports from Saudi Arabia alongside other countries. Furthermore, the purpose of this work is to demonstrate the genetic variations in the genes underlying the resistance mechanisms seen in MDR and XDR bacterial strains that have been reported in Saudi Arabia and other countries. To cover the gap, this comprehensive review explores the complex trends in antibiotic resistance and the growing risk posed by superbugs. We provide context on the concerning spread of drug-resistant bacteria by analyzing the fundamental mechanisms of antibiotic resistance and looking into individual case reports. In this article, we compiled various cases and stories associated with XDR and MDR strains from Saudi Arabia and various other countries including China, Egypt, India, Poland, Pakistan, and Taiwan. This review will serve as basis for highlighting the growing threat of MDR, XDR bacterial strains in Saudi Arabia, and poses the urgent need for national action plans, stewardship programs, preventive measures, and novel antibiotics research in the Kingdom.

show abstract

“…Furthermore, the patients in intensive care, on prolonged mechanical ventilation, and with ventilator-associated pneumonia could have contributed to the colonization with nosocomial pathogens and led to an improved number of resistant isolates [ 31 ]. Nowadays, AMR has nearly leveled off in some high-income countries, but it continues to rise in low- and middle-income countries (LMICs), such as South Asia, South America, and Africa [ 32 , 33 , 34 ]. What will happen in the future is unknown.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic

Catalano,

Iacopetta,

Ceramella

et al. 2023

Viruses

View full text Add to dashboard Cite

Antibacterial resistance is a renewed public health plague in modern times, and the COVID-19 pandemic has rekindled this problem. Changes in antibiotic prescribing behavior, misinformation, financial hardship, environmental impact, and governance gaps have generally enhanced the misuse and improper access to antibiotics during the COVID-19 pandemic. These determinants, intersected with antibacterial resistance in the current pandemic, may amplify the potential for a future antibacterial resistance pandemic. The occurrence of infections with multidrug-resistant (MDR), extensively drug-resistant (XDR), difficult-to-treat drug-resistant (DTR), carbapenem-resistant (CR), and pan-drug-resistant (PDR) bacteria is still increasing. The aim of this review is to highlight the state of the art of antibacterial resistance worldwide, focusing on the most important pathogens, namely Enterobacterales, Acinetobacter baumannii, and Klebsiella pneumoniae, and their resistance to the most common antibiotics.

show abstract

How can lessons from the COVID-19 pandemic enhance antimicrobial resistance surveillance and stewardship?

Cited by 20 publications

References 56 publications

Screening of Klebsiella pneumoniae subsp. pneumoniae Strains with Multi-Drug Resistance and Virulence Profiles Isolated from an Italian Hospital between 2020 and 2023

Screening of Klebsiella pneumoniae subsp. pneumoniae Strains with Multi-Drug Resistance and Virulence Profiles Isolated from an Italian Hospital between 2020 and 2023

Extensively and multidrug-resistant bacterial strains: case studies of antibiotics resistance

Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic

Contact Info

Product

Resources

About