How can the commercial potential of microalgae from the Dunaliella genus be improved? The importance of nucleotide metabolism with a focus on nucleoside diphosphate kinase (NDPK)

Woyda-Płoszczyca, Andrzej; Rybak, Andrzej

doi:10.1016/j.algal.2021.102474

Cited by 6 publications

(2 citation statements)

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“…graminearum in infected wheat and other cereal crops, such as deoxynivalenol (DON) and zearalenone, cause serious threats to human and animal health. , Previous studies showed that NDPKs are involved in the biosynthesis of a secondary metabolite. In Dunaliella tertiolecta, NDPKS-mediated nucleotide metabolism is crucial for the synthesis of carotenoids . DON mycotoxin, as a secondary metabolite of F.…”

Section: Introductionmentioning

confidence: 99%

“…In Dunaliella tertiolecta, NDPKS-mediated nucleotide metabolism is crucial for the synthesis of carotenoids. 18 DON mycotoxin, as a secondary metabolite of F. graminearum, has attracted much attention in harming the health of humans and animals. 19 The biosynthesis of DON is related to the trichothecene (TRI) genes, and the TRI biosynthetic pathway has been extensively characterized.…”

Section: Introductionmentioning

confidence: 99%

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Mitochondria-Associated Protein FgNdk1 Regulates the Development, Pathogenicity, and SDHI Fungicide Sensitivity of Fusarium graminearum by Interacting with Succinate Dehydrogenase

Wang,

Zhao,

et al. 2024

J. Agric. Food Chem.

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Nucleoside diphosphate kinase (NDK) plays an important role in many cellular processes in all organisms. In this study, we functionally characterized a nucleoside diphosphate kinase (FgNdk1) in Fusarium graminearum, a causal agent of Fusarium head blight (FHB). FgNdk1 was involved in the generation of energy in the electron-transfer chain by interacting with succinate dehydrogenase (FgSdhA, FgSdhC 1 , and FgSdhC 2 ). Deletion of FgNdk1 not only resulted in abnormal mitochondrial morphology, decreased ATP content, defective fungal development, and impairment in the formation of the toxisome but also led to the suppressed expression level of DON biosynthesis enzymes, decreased DON biosynthesis, and declined pathogenicity as well. Furthermore, deletion of FgNdk1 caused increasing transcriptional levels of FgSdhC 1 and FgdhC 2 , in the presence of pydiflumetofen, related to the decreased sensitivity to SDHI fungicides. Overall, this study identified a new regulatory mechanism of FgNdk1 in the pathogenicity and SDHI fungicide sensitivity of Fusarium graminearum.

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