How can we help haematological cancer survivors cope with the changes they experience as a result of their cancer?

Hall, Alix; Lynagh, Marita; Tzelepis, Flora; Paul, Chris; Bryant, Jamie

doi:10.1007/s00277-016-2806-8

Cited by 10 publications

(8 citation statements)

References 46 publications

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“…Several studies have been conducted to assess the differences between HASS and CASS, but the study on Chinese children is limited. Regarding the difference in basic diseases, published data have suggested that most blood malignancies in HASS patients can lead to immune deficiency, which is a risk factor for infection and death [19][20][21]. In addition, neutropenia was shown to be one of the factors that could increase the risk of infection [22].…”

Section: Discussionmentioning

confidence: 99%

Comparison between hospital- and community-acquired septic shock in children: a single-center retrospective cohort study

Fan

Fang

et al. 2022

World J Pediatr

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Background We explored the differences in baseline characteristics, pathogens, complications, outcomes, and risk factors between children with hospital-acquired septic shock (HASS) and community-acquired septic shock (CASS) in the pediatric intensive care unit (PICU). Methods This retrospective study enrolled children with septic shock at the PICU of Beijing Children’s Hospital from January 1, 2016, to December 31, 2019. The patients were followed up until 28 days after shock or death and were divided into the HASS and CASS group. Logistic regression analysis was used to identify risk factors for mortality. Results A total of 298 children were enrolled. Among them, 65.9% (n = 91) of HASS patients had hematologic/oncologic diseases, mainly with Gram-negative bacterial bloodstream infections (47.3%). Additionally, 67.7% (n = 207) of CASS patients had no obvious underlying disease, and most experienced Gram-positive bacterial infections (30.9%) of the respiratory or central nervous system. The 28-day mortality was 62.6% and 32.7% in the HASS and CASS groups, respectively (P < 0.001). Platelet [odds ratio (OR) = 0.996, 95% confidence interval (CI) = 0.992–1.000, P = 0.028], positive pathogen detection (OR = 3.557, 95% CI = 1.307–9.684, P = 0.013), and multiple organ dysfunction syndrome (OR = 10.953, 95% CI = 1.974–60.775, P = 0.006) were risk factors for 28-day mortality in HASS patients. Lactate (OR = 1.104, 95% CI = 1.022–1.192, P = 0.012) and mechanical ventilation (OR = 8.114, 95% CI = 1.806–36.465, P = 0.006) were risk factors for 28-day mortality in patients with CASS. Conclusions The underlying diseases, pathogens, complications, prognosis, and mortality rates varied widely between the HASS and CASS groups. The predictors of 28-day mortality were different between HASS and CASS pediatric patients with septic shock.

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Section: Discussionmentioning

confidence: 99%

Comparison between hospital- and community-acquired septic shock in children: a single-center retrospective cohort study

Fan

Fang

et al. 2022

World J Pediatr

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“…Studies state that patients with HASS were mainly older children with underlying diseases (76.9%); whereas, 65.9% patients had hematologic/oncologic diseases. Research also suggests that most of the blood malignancies in HASS patients can lead to immune de ciency, which is a risk factor for infection and death [15][16][17]. Compared with CASS, children with HASS had signi cantly lower WBCs and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Hospital- and Community-Acquired Septic Shock in Children: A Single-Center, Cohort, Retrospective Study

Fan

Fang

et al. 2021

Preprint

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Background To explore differences between hospital- (HASS) and community-acquired septic shock (CASS) in patient characteristics, pathogens, complications, outcomes, and risk factors in pediatric intensive care unit (PICU) children. Methods This retrospective study enrolled septic shock children from January 1, 2016, to December 31, 2019. The patients were followed up until 28 days after shock or death and were divided into HASS and CASS groups. After comparison, logistic regression analyses were used to identify risk factors for mortality. Results A total of 298 children were enrolled. 65.9% of HASS patients (N = 91) had hematological/tumor diseases and were mainly bloodstream infections of Gram-negative bacteria (47.3%). 67.7% of CASS (N = 207) had no obvious underlying disease and were mostly infected with Gram-positive bacteria (30.9%) of the respiratory or central nervous system. 28-day mortality was 62.6% and 32.7% in HASS and CASS groups, respectively (p < 0.001). The factor associated with 28-day mortality of HASS and CASS was MODS (OR:11.524; 95% CI: 2.140-62.051) and needed invasive mechanical ventilation therapy (OR:6.884; 95% CI: 1.499–31.624), respectively. Conclusions The underlying diseases, pathogens, complications, prognosis and mortality varied widely. 28-day mortality is associated with MODS and need for invasive mechanical ventilation therapy in HASS and CASS patients.

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“…A need for information regarding side effects and how to manage them was identified in eight studies, 22,[28][29][30][31][32][33][34] seven of which provide some evidence that this need was unmet for many rural cancer survivors. 22,[29][30][31][32][33][34] For example, survey results showed that 11%-47% of rural survivors reported not receiving information on managing the side effects of treatment.…”

Section: Managing Side Effects and Self-managementmentioning

confidence: 99%

What are the post‐treatment information needs of rural cancer survivors in Australia? A systematic literature review

et al. 2023

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Objective: To conduct a systematic literature review to critically assess the met and unmet post-treatment information needs of cancer survivors living in rural communities in Australia, to inform the improvement of survivors' transition from treatment in major cities to community care.Methods: Cumulative index of nursing and allied health literature, PubMed, Web of Science, Scopus, Cochrane CENTRAL and Academic Search Ultimate databases and websites of 118 cancer organisations were searched for relevant Australian studies published since 2006. Key search terms included 'rural', 'remote', 'regional', 'cancer', 'survivor*', 'living with', and 'post-treatment'. Data reflecting study source, aims, methodology, and reported information needs were extracted and summarised.Study quality was assessed using Joanna Briggs Institute tools.Results: Fifty-two articles met eligibility criteria. Only six of these specified a primary aim of understanding information needs for rural cancer survivors. Information on prognosis and recovery; managing treatment side effects; healthy lifestyle choices; referrals to support services, and face-to-face and written delivery of information at multiple time points were reported as needed and often lacking for rural cancer survivors.

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How can we help haematological cancer survivors cope with the changes they experience as a result of their cancer?

Cited by 10 publications

References 46 publications

Comparison between hospital- and community-acquired septic shock in children: a single-center retrospective cohort study

Comparison between hospital- and community-acquired septic shock in children: a single-center retrospective cohort study

Comparison of Hospital- and Community-Acquired Septic Shock in Children: A Single-Center, Cohort, Retrospective Study

What are the post‐treatment information needs of rural cancer survivors in Australia? A systematic literature review

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