2021
DOI: 10.1590/1516-4446-2020-0935
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How can we improve antidepressant adherence in the management of depression? A targeted review and 10 clinical recommendations

Abstract: Adherence to antidepressants is crucial for optimal treatment outcomes when treating depressive disorders. However, poor adherence is common among patients prescribed antidepressants. This targeted review summarizes the main factors associated with poor adherence, interventions that promote antidepressant adherence, pharmacological aspects related to antidepressant adherence, and formulates 10 clinical recommendations to optimize antidepressant adherence. Patient-related factors associated with antidepressant … Show more

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Cited by 46 publications
(45 citation statements)
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References 113 publications
(141 reference statements)
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“…Significantly, this emphasizes the necessity of greater attention to drug prescription safety provided after hospital discharge, as well as the necessity of providing psychoeducation and subsequent patient monitoring ( Riblet et al., 2017 ; Solmi et al., 2020 ; Yanagina et al., 2017 ; Zhao et al., 2015 ). Psychoeducation is an important strategy for providing patients with necessary information on safe drug use, and thus prevent suicide attempts and deaths ( Riblet et al., 2017 ; Solmi et al., 2020 ; Yanagida et al., 2017 ; Zhao et al., 2015 ).…”
Section: Discussionmentioning
confidence: 99%
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“…Significantly, this emphasizes the necessity of greater attention to drug prescription safety provided after hospital discharge, as well as the necessity of providing psychoeducation and subsequent patient monitoring ( Riblet et al., 2017 ; Solmi et al., 2020 ; Yanagina et al., 2017 ; Zhao et al., 2015 ). Psychoeducation is an important strategy for providing patients with necessary information on safe drug use, and thus prevent suicide attempts and deaths ( Riblet et al., 2017 ; Solmi et al., 2020 ; Yanagida et al., 2017 ; Zhao et al., 2015 ).…”
Section: Discussionmentioning
confidence: 99%
“…Significantly, this emphasizes the necessity of greater attention to drug prescription safety provided after hospital discharge, as well as the necessity of providing psychoeducation and subsequent patient monitoring ( Riblet et al., 2017 ; Solmi et al., 2020 ; Yanagina et al., 2017 ; Zhao et al., 2015 ). Psychoeducation is an important strategy for providing patients with necessary information on safe drug use, and thus prevent suicide attempts and deaths ( Riblet et al., 2017 ; Solmi et al., 2020 ; Yanagida et al., 2017 ; Zhao et al., 2015 ). One of the key recommendations is adequate orientation of patients to ensure drug safety after hospital discharge, performed by the healthcare team during patient hospitalization (especially for those with potential drug interaction presence and previous suicide attempts), considering the high risks related to health problems.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Another important point raised by Solmi et al 1 is that we continue to be hindered by our trial and error approach to depression treatment. We do a disservice to our patients by continuing to view depression as a behavioral disorder when the evidence indicates that it is a biological disorder of the brain, as well as that each individual has unique variations of genetics, brain structures, and other biological factors in addition to the psychosocial factors linked to depression.…”
mentioning
confidence: 99%
“…So, why do people who display enough depressive symptoms to warrant psychopharmacological treatment stop taking their medication? Solmi et al 1 provide an excellent review of factors that may be the leading causes of non-adherence to antidepressants. The authors classify these factors as patient-related or provider-related.…”
mentioning
confidence: 99%