How Did Covid-19 Pandemic Affect the Older Patients  Comparison of Clinical Features in Older Versus Younger Patients.

COVID-19 is a highly contagious and deadly disease. It may present with neurologic symptoms as well as respiratory symptoms. In this study, the existence of different biomarkers in the development and evaluation of neurologic symptoms and complications in patients with COVID-19 and the relationship between clinical course and neurologic disorders were investigated. In this prospective randomized study, the study group included 133 patients with a diagnosis of COVID-19 who were admitted to the neurology clinic and intensive care unit managed by expert neurologists during the pandemic period. Patients were classified as those without neurological disorders associated with COVID-19, those with mild neurologic disorders, and those with severe neurological disorders. The demographic characteristics, laboratory values, lung tomography, and clinical features of these patients were examined and the relationship between them was investigated. Of the patients, 54.9% were male, 45.1% were female, and the mean age was 60.85±18.38 (min-max: 19-91) years. As the age increased, a moderately significant positive correlation was found between the presence of neurologic disorders and disease severity. Myalgia (39.1%) and headache (34.6%) were the most common neurologic symptoms. In patients with severe neurologic disorders, the most common neurologic symptom was unconsciousness (n=22, 64.7%). Hemoglobin levels, hematocrit, lymphocyte counts, and procalcitonin levels were decreased (p=0.010, p=0.018, p=0.001, and p=0.021, respectively) in patients with neurologic disorders, neutrophil count, C-reactive protein, D-dimer, and interleukin-6 levels were increased (p=0.039, p=0.020, p<0.001, and p=0.001, respectively). An increase in the presence and severity of neurologic disorders was observed in patients in parallel with an increase in lung computed tomography scores and O2 requirement (p<0.001 and p<0.001, respectively). As the severity of the neurologic disorders of the patients increased, the rate of discharge decreased (p<0.001). Our results suggested that some biomarkers associated with the severity of the disease could also be shown in patients with neurologic disorders, and patients with COVID-19 had severe disease in the presence of neurologic disorders. To define the existence of an independent biomarker, there is a need for large-scale studies in which neurologic disorders are handled separately.

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“…points: 76-100%). Second, the scores of the five lobes were summed to obtain a total lung score ranging from 0 to 20 [7].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Biomarkers and Clinical Course in Patients Developing Neurologic Disorders due to COVID-19

Düzgün¹,

Sarı²,

Karadaş³

2022

jmvi

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COVID-19 Enfeksiyonu Olan Geriatrik Hastalarda Yoğun Bakıma Yatışı Ve Mortaliteyi Etkileyen Faktörler

Şen,

Demirdal

2024

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi

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Amaç: COVID-19 pandemisinde yaşa bağlı hastalık insidansı ve ölüm oranlarının artış gösterdiği; özellikle komorbiditenin yanı sıra fiziksel, psikolojik ve sosyal etkenlerin yaşlı bireyleri diğer yaş gruplarına göre daha çok etkilediği bildirilmektedir. Çalışmamızda COVID-19 enfeksiyonu nedeniyle hastaneye yatırılan geriatrik hastalarda yoğun bakıma yatışı ve mortaliteyi etkileyen faktörleri belirlemeyi amaçladık. Yöntem: COVID-19 enfeksiyonu nedeniyle 1 Mayıs 2020 - 1 Ağustos 2020 tarihleri arasında yatırılarak izlenen 65 yaş ve üstü hastaların demografik, klinik ve laboratuvar verileri geriye dönük olarak değerlendirildi. İzleminde yoğun bakıma yatırılan ya da ölen hastalar çalışma grubu, serviste takibi devam eden ya da sağ kalan hastalar ise kontrol grubu olarak alındı. Tüm hastaların hastaneye yatış anında elde edilen verileri istatistiksel olarak değerlendirildi. Bulgular: Çalışmaya 151 hasta dahil edildi. Hastaların 76 (%50.3)’sı erkekti ve medyan yaş 75 yıl (69-83 yıl) idi. En az bir komorbid hastalık bulunan 106 (%70.2) hasta vardı. Servis izleminde 53 (%35.1) hasta yoğun bakıma alınırken, tüm hastaların 38 (%25.2)’ i kaybedildi. Serum glukoz, AST, ALT, direk bilirubin, CRP, prokalsitonin, lökosit, lenfosit, nötrofil, D-dimer, ferritin, PT ve INR düzeyleri hem yoğun bakıma yatan hem de ölen hastalarda anlamlı parametreler iken; serum kreatinin ve troponin düzeyleri sadece ölen hastalarda daha yüksek saptandı. Sonuç: COVID-19 enfeksiyonu nedeniyle hastaneye yatırılan yaşlı hastaların başvuruları sırasında nefes darlığı olması ve bozulmuş laboratuvar değerleri yoğun bakıma yatış ve prognoz açısından yol gösterici potansiyele sahiptir.

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How Did Covid-19 Pandemic Affect the Older Patients Comparison of Clinical Features in Older Versus Younger Patients.

Cited by 2 publications

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Evaluation of Biomarkers and Clinical Course in Patients Developing Neurologic Disorders due to COVID-19

Evaluation of Biomarkers and Clinical Course in Patients Developing Neurologic Disorders due to COVID-19

COVID-19 Enfeksiyonu Olan Geriatrik Hastalarda Yoğun Bakıma Yatışı Ve Mortaliteyi Etkileyen Faktörler

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