The SARS-CoV-2 lineage B.1.1.7 (Alpha) has spread to 114 countries around the world since it was first detected in the UK in September 2020 (P. Wang, Nair, et al., 2021). Some studies have shown that B.1.1.7 is not only 43%-90% (95% CI 38-130) more transmissible than preexisting variants (Jewell, 2021;Walensky et al., 2021) but also causes more severe illness (Davies et al., 2021;Patone et al., 2021). With the accelerated vaccination, the world is gradually entering a regular prevention and control stage (Pham et al., 2021) with some regions preparing to reopen to the world (Chang et al., 2021;Zhao et al., 2021). In order to assist these regions to effectively prevent the emergence of new variants in the reopening process, it became crucial to explore the nonpharmaceutical intervention (NPI) measures that affect the emergence and spread of SARS-CoV-2 variants such as B.1.1.7 and thereby, first learn in general how to effectively control the spatiotemporal spread of SARS-CoV-2 variants. Taiwan, one of the regions where B.1.1.7 appeared during the reopening process (Shonchoy et al., 2021;Tan, 2021;Yu et al., 2021), is chosen regarding the exploration of the spatial dynamics of the B.1.1.7 spread and investigation with the aim of exploring relevant data and thereby finding the potential means to effectively control the spatiotemporal spread of B.1.1.7, potentially by the integration of vaccination and NPI measures.