2021
DOI: 10.1002/jgh3.12560
|View full text |Cite
|
Sign up to set email alerts
|

How did the ancient bacterium, Helicobacter pylori, cause an epidemic of chronic duodenal ulceration?

Abstract: The association of Helicobacter pylori with chronic duodenal ulceration was a seminal observation in the short history of gastroenterology. However, H. pylori is now known to be an ancient bacterium, whereas there is persuasive evidence that the epidemic of duodenal ulceration began in the second half of the 19th century and continued into the second half of the 20th century. Possible explanations for the epidemic include genomic changes in the organism and environmental or other influences on the human host. … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
5
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(5 citation statements)
references
References 58 publications
0
5
0
Order By: Relevance
“…Strain-specific virulent factors have been linked to a more severe grade of mucosal inflammation that may promote the presence of duodenal ulcer disease [ 22 ]; however, studies from the East Asian strain have disclosed inconsistent results [ 23 , 24 , 25 , 26 ]. Conceivably, factors other than bacterial virulence [ 27 ], the adopted classification of gastritis or the activity of DU should be considered in the interpretation of these findings.…”
Section: Discussionmentioning
confidence: 99%
“…Strain-specific virulent factors have been linked to a more severe grade of mucosal inflammation that may promote the presence of duodenal ulcer disease [ 22 ]; however, studies from the East Asian strain have disclosed inconsistent results [ 23 , 24 , 25 , 26 ]. Conceivably, factors other than bacterial virulence [ 27 ], the adopted classification of gastritis or the activity of DU should be considered in the interpretation of these findings.…”
Section: Discussionmentioning
confidence: 99%
“…pylori to breed and harm gastric lining cells. This harm can cause peptic and duodenal ulcers in the short term and chronic inflammation and gastric cancer in the long term …”
Section: Introductionmentioning
confidence: 99%
“…This harm can cause peptic and duodenal ulcers in the short term and chronic inflammation and gastric cancer in the long term. 8 Numerous attempts have been made to design new drugs with multiple mechanisms to eradicate this group of bacteria and prevent the progression of Helicobacter pylori-induced gastric cancer. One of these attempts is to inhibit the urease enzyme for the purpose of preventing the escape from acidic pH.…”
Section: Introductionmentioning
confidence: 99%
“…A separate but smaller group has an increase in acid secretion with H. pylori with minimal inflammation in the body of the stomach and is at higher risk for duodenal ulceration. In this group, eradication of infection results in a fall in acid secretion, largely because of a fall in serum gastrin 24 . As eradication of infection increases acid secretion in a substantial majority, the overall effect is an increase in the acid secretion that increases the risk of GERD.…”
mentioning
confidence: 99%
“…In this group, eradication of infection results in a fall in acid secretion, largely because of a fall in serum gastrin. 24 As eradication of infection increases acid secretion in a substantial majority, the overall effect is an increase in the acid secretion that increases the risk of GERD. By extension, more prominent esophageal inflammation could increase the risk of Barrett's esophagus and the subsequent risk of adenocarcinoma.…”
mentioning
confidence: 99%