How different are marine microbial natural products compared to their terrestrial counterparts?

Voser, Tanja M.; Campbell, Max D.; Carroll, Anthony Richard

doi:10.1039/d1np00051a

Cited by 54 publications

(50 citation statements)

References 94 publications

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“…Actinomycete sources alone account for approximately 80% of novel antibiotics derived from the marine environment [178]. Studies targeting specific and understudied marine microbial phyla can result in a greater likelihood of finding specific marine compounds, since most compounds isolated from marine microorganisms are closely related to compounds isolated from terrestrial microorganisms [221]. Unfortunately, the marine environment is one of the most under-explored environments, but still holds as a promising source of new and innovative natural products [220], which is clearly illustrated in Figure 4.…”

Section: Marine Streptomyces As a Source Of Antibioticsmentioning

confidence: 99%

Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective

Donald

Pipite

Subramani

et al. 2022

Microbiology Research

102

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There is a real consensus that new antibiotics are urgently needed and are the best chance for combating antibiotic resistance. The phylum Actinobacteria is one of the main producers of new antibiotics, with a recent paradigm shift whereby rare actinomycetes have been increasingly targeted as a source of new secondary metabolites for the discovery of new antibiotics. However, this review shows that the genus Streptomyces is still the largest current producer of new and innovative secondary metabolites. Between January 2015 and December 2020, a significantly high number of novel Streptomyces spp. have been isolated from different environments, including extreme environments, symbionts, terrestrial soils, sediments and also from marine environments, mainly from marine invertebrates and marine sediments. This review highlights 135 new species of Streptomyces during this 6-year period with 108 new species of Streptomyces from the terrestrial environment and 27 new species from marine sources. A brief summary of the different pre-treatment methods used for the successful isolation of some of the new species of Streptomyces is also discussed, as well as the biological activities of the isolated secondary metabolites. A total of 279 new secondary metabolites have been recorded from 121 species of Streptomyces which exhibit diverse biological activity. The greatest number of new secondary metabolites originated from the terrestrial-sourced Streptomyces spp.

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Section: Marine Streptomyces As a Source Of Antibioticsmentioning

confidence: 99%

Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective

Donald

Pipite

Subramani

et al. 2022

Microbiology Research

102

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“…An interesting recent review by Voser et al [63] on "How different are marine microbial natural products compared to their terrestrial counterparts?" did an excellent job of summarizing 55,817 compounds reported from marine and terrestrial microorganisms and showed that 76.7% of the compounds isolated from marine microorganisms are closely related to compounds isolated from terrestrial microorganisms.…”

Section: Marine Actinomycetes: a Potential Frontier Of Bioactive Comp...mentioning

confidence: 99%

Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites

et al. 2022

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Microbial secondary metabolites are an important source of antibiotics currently available for combating drug-resistant pathogens. These important secondary metabolites are produced by various microorganisms, including Actinobacteria. Actinobacteria have a colossal genome with a wide array of genes that code for several bioactive metabolites and enzymes. Numerous studies have reported the isolation and screening of millions of strains of actinomycetes from various habitats for specialized metabolites worldwide. Looking at the extent of the importance of actinomycetes in various fields, corals are highlighted as a potential hotspot for untapped secondary metabolites and new bioactive metabolites. Unfortunately, knowledge about the diversity, distribution and biochemistry of marine actinomycetes compared to hard corals is limited. In this review, we aim to summarize the recent knowledge on the isolation, diversity, distribution and discovery of natural compounds from marine actinomycetes associated with hard corals. A total of 11 new species of actinomycetes, representing nine different families of actinomycetes, were recovered from hard corals during the period from 2007 to 2022. In addition, this study examined a total of 13 new compounds produced by five genera of actinomycetes reported from 2017 to 2022 with antibacterial, antifungal and cytotoxic activities. Coral-derived actinomycetes have different mechanisms of action against their competitors.

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“…Interestingly, Voser et al, in their recent review using fingerprint cluster analysis, based on the MarineLit database, which covers compounds isolated from the marine environment between 1956 and 2020, and the NPAtlas database, which contains compounds isolated from microorganisms and published between 1877 and 2020, have found that marine fungal natural products (NPs) are nested with terrestrial fungal NPs at a relatively high proportion (74.6%). This indicates that marine and terrestrial fungi are more likely to share common biosynthetic gene clusters, or that marine sources of fungi are likely to be terrestrial “wash-ins” [ 65 ]. The authors have also found that most studies used potato dextrose or rice in sea water or sea salt as culture media for most of the marine-derived fungi.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Bioactive Compounds from Terrestrial and Marine-Derived Fungi of the Genus Neosartorya †

et al. 2022

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Fungi comprise the second most species-rich organism group after that of insects. Recent estimates hypothesized that the currently reported fungal species range from 3.5 to 5.1 million types worldwide. Fungi can grow in a wide range of habitats, from the desert to the depths of the sea. Most develop in terrestrial environments, but several species live only in aquatic habitats, and some live in symbiotic relationships with plants, animals, or other fungi. Fungi have been proved to be a rich source of biologically active natural products, some of which are clinically important drugs such as the β-lactam antibiotics, penicillin and cephalosporin, the immunosuppressant, cyclosporine, and the cholesterol-lowering drugs, compactin and lovastatin. Given the estimates of fungal biodiversity, it is easy to perceive that only a small fraction of fungi worldwide have ever been investigated regarding the production of biologically valuable compounds. Traditionally, fungi are classified primarily based on the structures associated with sexual reproduction. Thus, the genus Neosartorya (Family Trichocomaceae) is the telemorphic (sexual state) of the Aspergillus section known as Fumigati, which produces both a sexual state with ascospores and an asexual state with conidiospores, while the Aspergillus species produces only conidiospores. However, according to the Melbourne Code of nomenclature, only the genus name Aspergillus is to be used for both sexual and asexual states. Consequently, the genus name Neosartorya was no longer to be used after 1 January 2013. Nevertheless, the genus name Neosartorya is still used for the fungi that had already been taxonomically classified before the new rule was in force. Another aspect is that despite the small number of species (23 species) in the genus Neosartorya, and although less than half of them have been investigated chemically, the chemical diversity of this genus is impressive. Many chemical classes of compounds, some of which have unique scaffolds, such as indole alkaloids, peptides, meroterpenes, and polyketides, have been reported from its terrestrial, marine-derived, and endophytic species. Though the biological and pharmacological activities of a small fraction of the isolated metabolites have been investigated due to the available assay systems, they exhibited relevant biological and pharmacological activities, such as anticancer, antibacterial, antiplasmodial, lipid-lowering, and enzyme-inhibitory activities.

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How different are marine microbial natural products compared to their terrestrial counterparts?

Abstract: Cheminformatics analysis shows that most marine microbial natural products are like terrestrial microbial natural products. New methods to access novel marine microbial chemistry are needed.

Cited by 54 publications

References 94 publications

Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective

Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective

Marine Actinomycetes Associated with Stony Corals: A Potential Hotspot for Specialized Metabolites

Bioactive Compounds from Terrestrial and Marine-Derived Fungi of the Genus Neosartorya †

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