This article proposes a novel conceptualization of knowledge-intensive innovative entrepreneurship, which can capture the main characteristics of a vital phenomenon in the modern economy. Our conceptualization is based upon the integration of Schumpeterian entrepreneurship, evolutionary economics, and innovation systems approach. It consists of a theoretical definition and a stylized process model. According to this view, knowledgeintensive innovative entrepreneurs are involved in the creation, diffusion, and use of knowledge; introduce new products and technologies; draw resources and ideas from their innovation system; and introduce change and dynamism into the economy. In the article, we also offer an empirical definition of knowledge-intensive innovative entrepreneurship, which we then use to identify its key characteristics and relevance. We conclude with recommendations for a future research agenda.