How Do Patients Who Fail First-Line TB Treatment but Who Are Not Placed on an MDR-TB Regimen Fare in South India?

Nagaraja, Sharath Burugina; Satyanarayana, Srinath; Chadha, Sarabjit; Kalemane, Santosha; Jaju, Jyoti; Achanta, Shanta; Reddy, Kishore; Potharaju, Vishnu; Shamrao, Srinivas Rao Motta; Dewan, Puneet; Zachariah, Rony; Tetali, Shailaja; Anchala, Raghupathy; Kannuri, Nanda Kishore; Harries, Anthony; Singh, Sachdeva Kuldeep

doi:10.1371/journal.pone.0025698

Cited by 13 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study also revealed that INH resistance is seen in 39% cases in this geographical area. According to Burugina Nagaraja et al .,[ 6 ] treatment outcomes of patients who fail a first-line anti-TB therapy and who are not placed on an MDR-TB regimen are unacceptably poor. [ 6 ] Hence, there is a need to start MDR-TB regimen in cases of drug resistant TB other than MDR.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of multidrug resistance among retreatment pulmonary tuberculosis cases in a tertiary care hospital, Hyderabad, India

et al. 2013

View full text Add to dashboard Cite

Background:India is one of the high tuberculosis (TB) burden countries in the world. India ranks second in harboring multi drug resistant (MDR)-TB cases. About 50,000 of MDR cases are recorded in retreatment pulmonary TB cases. This study was conducted in a tertiary care facility (Government General and Chest Hospital) in Hyderabad, India.Objectives:Toassess: Proportion of the TB patients having MDR-TB at the initiation of retreatment regimen; the prevalence of isoniazid (INH) resistance in this geographical area.Materials and Methods:An analytical, observational, prospective cohort study of patients attending the out-patient department from December 2010 to March 2011.Results:Sputum samples from 100 patients were subjected to acid fast bacilli (AFB) culture and drug sensitivity testing. Of these, 28 (28%) were MDR-TB, 42 (42%) were non-MDR-TB and 39% being INH resistance.Conclusions:In conclusion, one third of the retreatment pulmonary TB cases attending a tertiary care institute for TB will be MDR-TB at the initiation of treatment and there is a need to include ethambutol in the continuation phase of new TB case treatment in view of high INH resistance.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of multidrug resistance among retreatment pulmonary tuberculosis cases in a tertiary care hospital, Hyderabad, India

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Unfinished first-line TB treatment has emerged as a large proportion of MDR-TB incidences, consisting of failure, default and relapse of TB treatment [3,5]. Management of TB therapy on non-directly observed treatments (DOTs) at health facilities [3,6], the lack of a gold standard of drug-susceptibility facilities for diagnosis [7,8] and poor TB patient access to medication [5,[8][9][10] are the main determinant factors for MDR-TB control, which is more complex in an under-resourced country setting.…”

Section: Background Rationalementioning

confidence: 99%

Unfinished first-line tuberculosis treatment in primary care in Indonesia

Asyary¹,

Mahendradhata²

2019

fmpcr

View full text Add to dashboard Cite

Background. Unfinished tuberculosis (TB) treatment has slowly but surely become an unexpected event in the disease's development into drug-resistant TB. Developing countries, mostly comprised of Asian and Eastern European countries, including Indonesia, have been overwhelmed in preventing drug-resistant TB outcomes and have also failed to avoid the development of this disease. Objectives. This review discusses the current issue of an unfinished first-line TB treatment strategy in primary care in Indonesia, presenting some relevant strategies in developing countries. Material and methods. A narrative review approach conducted on all existing evidence in selected scientific bibliographic sources. The researchers defined the keywords based on the research question as a search strategy. Results. Scarce resources and limited access, alongside national policy on TB control and management, contribute in different ways to impede first-line TB treatment in Indonesia. Empowerment of TB patients and their families are considered the best ways to increase awareness on TB medication in a low-to middle-income setting. The role of the hospital and private practitioner networks in the treatment and management of TB patients is essential for developing active-case-finding-approach programs for TB suspects in primary care in an Indonesian setting. Contrarily, the potential misunderstandings in TB treatment have led to peculiar events affected by poor surveillance systems for TB investigation contacts to prevent TB incidences in large populations. Conclusions. This study addressed the barrier of all stakeholders, particularly primary care, to achieve the Indonesian government's goals of TB elimination by 2030 and zero TB findings by 2050.

show abstract

“…With the long course of treatment and side effects, most people in the affected regions stopped taking medication when they started feeling well without completing the required dosage (Hedt et al 2011 ; Rahman et al 2014 ) . This behaviour resulted in development of bacteria that were able to withstand the drugs used for treatment (Almeida Da Silva and Palomino 2011 ; Chadha et al 2011 ; Daniel and Osman 2011 ; Hoek et al 2009 ; Nagaraja et al, 2011 ; States et al 2006 ; Tang et al 2013 ; WHO, 2010 ) . By cutting short the course of treatment, it meant that there was reduced drug pressure on the disease causing bacteria, which were then able to survive the treatment, and became more resilient.…”

Section: Disease Impact and Case Scenariosmentioning

confidence: 99%

Infectious Diseases and Livelihoods

Mphande

2016

Infectious Diseases and Rural Livelihood in Developing Countries

View full text Add to dashboard Cite

Agriculture has been the most common form of livelihood for rural communities in developing countries for centuries. Apart from providing a livelihood, rural communities find food and nutrients necessary for their survival and well-being from their farms. Agriculture also brings risks to health through infectious diseases. Poor health leads to reduction in productivity, where individuals are not able to carry out their livelihoods due to ill health. This could lead to reduction in income through excess expenditure on treatments, thereby inhibiting economic development of the affected communities. Infectious diseases have both direct and indirect impact on livelihoods. The direct impact includes poor health and loss of lives, which leads to partial and complete loss of livelihoods. Indirectly, infectious diseases lead to loss of income through poor performance of livelihoods as well as diversion of resources that could have been used to improve livelihood to seek medical treatment. Due to the effects of disease, individuals become marginalized, socially affecting their businesses and ways of earning a livelihood.

show abstract

How Do Patients Who Fail First-Line TB Treatment but Who Are Not Placed on an MDR-TB Regimen Fare in South India?

Cited by 13 publications

References 4 publications

Prevalence of multidrug resistance among retreatment pulmonary tuberculosis cases in a tertiary care hospital, Hyderabad, India

Prevalence of multidrug resistance among retreatment pulmonary tuberculosis cases in a tertiary care hospital, Hyderabad, India

Unfinished first-line tuberculosis treatment in primary care in Indonesia

Infectious Diseases and Livelihoods

Contact Info

Product

Resources

About