The research's goal is to evaluate the impact of entrepreneurship on Total Quality Management via an empirical examination of personnel from Jordan's national institutions. The research used explanatory analyzing methodology (quantitative), which was applied to the study sample, which consists of (unit/department manager, department head, supervisor or engineer, administrative employee). The sample was random, amounting to (375) participants according to Stephen Thompson's equation. The questionnaires were distributed to the study sample: (345) were retrieved, (12), invalid for analysis, were excluded and (335) valid responses, from the study community, were analyzed, with a percentage of (89.3%). The information was analyzed using the Statistical Package for Social Sciences (SPSS) application. The research found a statistically meaningful impact at the level of relevance (α ≤ 0.05) between entrepreneurship and Total Quality Management in public universities in Jordan, where the value reached (R² = 16.4%). Moreover, the study recommended the need to work on investing and transforming new innovative ideas and solutions, turning them to useful services and processes that can be used. Other recommendations included increasing the concern for continuous improvement of its services and processes, and working to provide a suitable environment (working environment) for the creation of methods and ideas.