How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?

Vaseghi, Salar; Nasehi, Mohammad; Zarrindast, Mohammad‐Reza

doi:10.1016/j.neubiorev.2020.10.018

Cited by 13 publications

(16 citation statements)

References 615 publications

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“…In terms of localization at the central level, CB1Rs are found almost in all synapses, mainly in the basal ganglia, hippocampus, cerebellum, neocortex and hypothalamus [25,52]. CB1R can be found in presynaptic or postsynaptic levels in glutamatergic synapses, being able to control excessive-glutamate release and an overactivation of glutamatergic receptors [53].…”

Section: Endocanabinoid Receptorsmentioning

confidence: 99%

“…High CB2R mRNA was also expressed in the spleen [48,60]. Its expression can increase up to 100-fold in inflammatory processes, after injuring the tissues, in brain trauma, or in various pathological states [25,52]. CB2R can also be found in CNS within astrocytes, brainstem and microglia in stressful conditions such as neuroinflammation.…”

Section: Endocanabinoid Receptorsmentioning

confidence: 99%

“…memory, learning, affective parameters, etc.) via their interactions with neurotransmitters, cannabinoids could have a positive effect on these type of diseases [52,76].…”

Section: Neuroprotection Rolesmentioning

confidence: 99%

“…Learning and memory impairment can be considered the most relevant side effects of cannabinoids, effects mainly mediated by CB1R through their activation. These issues have been observed in numerous studies conducted on rats and mice, which have evaluated the effects of agonists such as arachidonyl-cyclopropyl amide (ACPA) and antagonists (AM251) of CB1Rs, on spatial memory and learning processes, where agonists caused cognitive impairments and antagonists often enhanced memory and learning processes [52,81].…”

Section: Cannabinoids and Alzheimer's Diseasementioning

confidence: 99%

“…∆ 9 -THC interacts with central CB1Rs and peripheral CB2Rs, leading to affective, cognitive, sensory and somatic effects. It also has neuroprotective properties in cerebral ischaemia and hypoxia, improving ocular circulation [52,75]. Treatment with ∆ 9 -THC before ischemia challenge reduced infarct size, while pre-and post-ischemic treatment with CBD showed strong and longerlasting neuroprotection.…”

Section: Cannabinoids and Alzheimer's Diseasementioning

confidence: 99%

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Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty

Vasincu

Rusu

Ababei

et al. 2022

Biology

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Neurodegenerative diseases are an increasing cause of global morbidity and mortality. They occur in the central nervous system (CNS) and lead to functional and mental impairment due to loss of neurons. Recent evidence highlights the link between neurodegenerative and inflammatory diseases of the CNS. These are typically associated with several neurological disorders. These diseases have fundamental differences regarding their underlying physiology and clinical manifestations, although there are aspects that overlap. The endocannabinoid system (ECS) is comprised of receptors (type-1 (CB1R) and type-2 (CB2R) cannabinoid-receptors, as well as transient receptor potential vanilloid 1 (TRPV1)), endogenous ligands and enzymes that synthesize and degrade endocannabinoids (ECBs). Recent studies revealed the involvement of the ECS in different pathological aspects of these neurodegenerative disorders. The present review will explore the roles of cannabinoid receptors (CBRs) and pharmacological agents that modulate CBRs or ECS activity with reference to Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD) and multiple sclerosis (MS).

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Section: Endocanabinoid Receptorsmentioning

confidence: 99%

Section: Endocanabinoid Receptorsmentioning

confidence: 99%

“…memory, learning, affective parameters, etc.) via their interactions with neurotransmitters, cannabinoids could have a positive effect on these type of diseases [52,76].…”

Section: Neuroprotection Rolesmentioning

confidence: 99%

Section: Cannabinoids and Alzheimer's Diseasementioning

confidence: 99%

Section: Cannabinoids and Alzheimer's Diseasementioning

confidence: 99%

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Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty

Vasincu

Rusu

Ababei

et al. 2022

Biology

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The interaction between cannabinoids and long‐term synaptic plasticity: A survey on memory formation and underlying mechanisms

Azarfarin,

Ghadiri,

Dadkhah

et al. 2024

Cell Biochemistry & Function

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Synaptic plasticity, including long‐term potentiation (LTP) and long‐term depression (LTD), is an essential phenomenon in memory formation as well as maintenance along with many other cognitive functions, such as those needed for coping with external stimuli. Synaptic plasticity consists of gradual changes in the biochemistry and morphology of pre‐ and postsynaptic neurons, particularly in the hippocampus. Consuming marijuana as a primary source of exocannabinoids immediately impairs attention and working memory‐related tasks. Evidence regarding the effects of cannabinoids on LTP and memory is contradictory. While cannabinoids can affect a variety of specific cannabinoid receptors (CBRs) and nonspecific receptors throughout the body and brain, they exert miscellaneous systemic and local cerebral effects. Given the increasing use of cannabis, mainly among the young population, plus its potential adverse long‐term effects on learning and memory processes, it could be a future global health challenge. Indeed, the impact of cannabinoids on memory is multifactorial and depends on the dosage, timing, formula, and route of consumption, plus the background complex interaction of the endocannabinoids system with other cerebral networks. Herein, we review how exogenously administrated organic cannabinoids, CBRs agonists or antagonists, and endocannabinoids can affect LTP and synaptic plasticity through various receptors in interaction with other cerebral pathways and primary neurotransmitters.

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Cannabidiol Plays a Modulatory Function on the Methamphetamine-Induced Reward Through Hippocampal D2-Like Dopamine Receptors

Mohammadi,

Omidiani,

Azizbeigi

et al. 2024

Neurochem Res

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How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?

Cited by 13 publications

References 615 publications

Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty

Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty

The interaction between cannabinoids and long‐term synaptic plasticity: A survey on memory formation and underlying mechanisms

Cannabidiol Plays a Modulatory Function on the Methamphetamine-Induced Reward Through Hippocampal D2-Like Dopamine Receptors

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