“…Yet, the scientific evidence is slim regarding the correlation between risk of apical flare‐up and time since root–canal treatment (Yu, Messer, Shen, et al, 2012; Yu, Messer, Yee, & Shen, 2012). Overall, studies on exacerbation of post‐endodontic apical lesions are scarce (Pigg et al, 2022; Yu, Messer, Shen, et al, 2012; Yu, Messer, Yee, & Shen, 2012), which renders the prediction of such events difficult. The same can be said regarding apical lesions in medically compromised patients.…”