How Do We Bridge the West and the East in the Treatment for Gastric Cancer?

Abstract

In 2012, gastric cancer (GC) was the fifth most common malignancy and the third leading cause of cancer death in the world. 1 The prevalence of GC remains more common in countries of the Far East, including Japan and Korea, than in countries of the West.2 Moreover, better overall survival (OS) has been reported in Eastern trials than the Western series (East vs West 5-year OS: 60-70 vs 30-40 %) [3][4][5][6][7] Eastern investigators may argue that this difference is attributable to more radical surgery, whereas Western investigators may claim that this difference is attributable to earlier detection and differences in biology. 8,9 Recently, Ikoma et al. 10,11 at MD Anderson Cancer Center, in which the standard extent of lymph node dissection has been D2, reported the factors contributing to lymph node metastasis and the 5-year OS of patients with pathologic stage T1 or T2 GC. In their single-institution retrospective study, 122 patients with T1 or T2 GC who underwent R0 resection without preoperative treatment were examined.10,11 Extended lymph node dissection (D1 ?/D2) was performed for 55 % of the patients.11 As a result, race, T1b stage or higher, and 15 or more lymph nodes examined were risk factors for lymph node metastasis, 10 whereas T2 stage, but not race or nodal status, was the only variable independently associated with 5-year OS.11 The lymph node metastasis rates were 10 % for stage T1a, 34 % for stage T1b, and 44 % for stage T2 tumor. 10The 5-year OS was 98 % for stage T1a, 93 % for stage T1b, and 66 % for stage T2 tumors.11 Collectively, surgical resection with locoregional lymph node dissection mostly cured early GC, although the rates for lymph node metastasis were higher for each T stage than those found in reports from Asia.10,11 Although their study had a couple of limitations, including its retrospective design and relatively small sample due to their preference for preoperative therapy used for T2 stage or higher, N ? tumor, or both, 10,11 these outcomes suggest that indications for endoscopic resection (ER) should be more confined, at least in their region than in Japan, in which ER has been extensively indicated for early GC.In reality, many clear differences that may account for better long-term outcomes in the East than in the West exist, namely, earlier detection of GC because of mass cancer screening programs based on higher incidence, 12 pathologic evaluation focused more on nuclear cytologic and glandular architecture abnormalities, 13-15 tumor biology including more distal location as well as more differentiated histology, 9 wider adoption of ER for early GC and D2 lymphadenectomy for advanced GC,8,9 and less frequent use of preoperative chemotherapy.16 However, because Japanese and Korean physicians have been building a therapeutic algorithm for the treatment for GC 17 over time according to their abundant experience and evidence based on their high quality of pathologic [13][14][15] and endoscopic 18 diagnosis combined with that of endoscopic and surgical treatment, including ER an...

Incidence and Grading of Complications After Gastrectomy for Cancer Using the GASTRODATA Registry

“…Young patients with BMI <20 kg/m 2 , an ASA score of 1, and a Charlson Comorbidity Index of 0 comprised less than 10% of the study population, whereas these characteristics are typically present, on average, in 50% of patients in eastern series. 24,25 The clinical and oncological features of the 1349 patients analyzed in this study were also typically western; at least half of patients had lost weight, half of them underwent neoadjuvant chemotherapy, 60% had T3/T4 cancer, while only 20% of patients had early gastric cancers; corresponding values of these parameters in the eastern series are 20%, 20%, 30%, and 60%. 25 The proximal localization of the tumor or linitis plastica was reported in 60% of cases, against an average of 30% in the eastern series.…”