“How do we rally around the one who was positive?” Familial uncertainty management in the context of men managing BRCA-related cancer risks

Rauscher, Emily; Dean, Marleah; Campbell‐Salome, Gemme; Barbour, Joshua B.

doi:10.1016/j.socscimed.2019.112592

Cited by 24 publications

(32 citation statements)

References 35 publications

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“…The response to cascade screening was higher for female than for male index participants, indicating the need for improved communication with gender-specific heritable disorders. 38,39 The contacting of family members for cascade screening is one way to maximize the impact of a population biobank, and further investigation is needed to determine the best way to increase response rates for optimization of this cascade approach.…”

Section: Potential Of Existing Datasetsmentioning

confidence: 99%

Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants

et al. 2020

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Section: Potential Of Existing Datasetsmentioning

confidence: 99%

Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants

et al. 2020

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“…For some men, concern for the health of existing or potential daughters or granddaughters is a key motivation for seeking BRCA testing 2930. In contrast, sometimes men are reluctant to have BRCA testing because they are concerned about potentially having passed a cancer-predisposing BRCA variant on to their children.…”

Section: Case Studiesmentioning

confidence: 99%

Care of men with cancer-predisposingBRCAvariants

Horton

Pharoah

Hayward³

et al. 2021

BMJ

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“…Through such counseling, practitioners can advise female family members to make at-risk men the subject of the narrative at times to help men better recognize their risks. Receiving this genetic risk information from a trusted family member might enhance the likelihood that the men engage in information seeking about BRCA-related cancer risks, genetic counseling, and testing, and ultimately employ proactive decision-making (Rauscher et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Engaging Men With BRCA-Related Cancer Risks: Practical Advice for BRCA Risk Management From Male Stakeholders

2020

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Men are at risk for developing hereditary cancers such as breast, prostate, pancreatic, and melanoma due to a pathogenic germline variant in either the BRCA1 or BRCA2 gene. The purpose of this study was to identify and provide practical advice for men managing their BRCA-related cancer risks based on men’s real-life experiences. Semistructured interviews were conducted with 25 men who either tested positive for a pathogenic variant in BRCA1/2 gene or who had an immediate family member who had tested positive for a pathogenic variant in BRCA1/2. A thematic analysis of the interview transcripts was completed utilizing the constant comparison method. Qualitative analysis produced three categories of participant advice for men who recently learned of their hereditary cancer risk. Specifically, participants advised the following: (a) know the basics, (b) engage in the family narrative, and (c) advocate for yourself. Results showed the need for men to know and understand their BRCA cancer risks and communicate that genetic risk information to their family members and practitioners. In particular, the findings stress the importance of addressing men’s risks and medical management from a family-focused approach. Overall, because men are historically undereducated about their BRCA-related cancer risks, this practical advice serves as a first step for men managing BRCA-related cancer risks and may ultimately assist them in making preventive and screening health behaviors.

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“How do we rally around the one who was positive?” Familial uncertainty management in the context of men managing BRCA-related cancer risks

Cited by 24 publications

References 35 publications

Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants

Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants

Care of men with cancer-predisposingBRCAvariants

Engaging Men With BRCA-Related Cancer Risks: Practical Advice for BRCA Risk Management From Male Stakeholders

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