2011
DOI: 10.2164/jandrol.111.013029
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How Do You Get Six Meters of Epididymis Inside a Human Scrotum?

Abstract: It is very clear that the epididymis plays a crucial role in the maturation of spermatozoa, and without a fully developed and functional epididymis, male infertility will result. We are especially interested in understanding the mechanisms that regulate the development of this important organ because disruptions to epididymal function will also arise as a consequence of abnormal development. Very little is known either of the process of epididymal development or the nature and causes of congenital defects that… Show more

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Cited by 55 publications
(50 citation statements)
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“…The process of elongation is likely a product of potential mechanisms such as cell proliferation coupled with directed cell rearrangements, along with the interactions between the Wolffian duct ephitelium and the surrounding mesenchyme cells (Hinton et al, 2011).…”
Section: The Prenatal Development Of the Epididymismentioning
confidence: 99%
See 1 more Smart Citation
“…The process of elongation is likely a product of potential mechanisms such as cell proliferation coupled with directed cell rearrangements, along with the interactions between the Wolffian duct ephitelium and the surrounding mesenchyme cells (Hinton et al, 2011).…”
Section: The Prenatal Development Of the Epididymismentioning
confidence: 99%
“…While cell proliferation in the Wolffian duct appears to be dependent on the presence of androgens and mesenchymal factors during prenatal development, lumicrine factors produced by the testicles play an additional role during postnatal development (Hinton et al, 2011). Lumicrine factors are molecules (such as androgens, growth factors and enzymes) whose effect on the secretory activity of the epithelial cells of the epididymis and in the epididymis spermatozoa directly participates in the process of epididymal maturation (Lan et al, 1998;.…”
Section: The Postnatal Development Of the Epididymismentioning
confidence: 99%
“…In general, the differentiation of epididymal epithelial cells appears in two developmental phases during postnatal development a first phase in the early neonatal period, in which halo cells appear from undifferentiated cells, and a second phase, in which there is a sequential differentiation of other cell types until adulthood (Arrotéia et al, 2012). It is believed that a number of lumicrine factors produced by the testis, such as androgens, growth factors, and other secretory molecules, play important roles in the differentiation of the epithelium (Hinton et al, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…As with many aspects of urogenital development, there is a progressive cranial to caudal progression in the onset of coiling. The pattern of coiling is not generated by differential rates of cell proliferation along the duct, as the rate of cell division appears to be uniform along the whole length [Hinton et al, 2011]. Possibly proliferation and coiling, whilst occurring at the same time, are under independent control [Hinton et al, 2011].…”
Section: Forming the Epididymismentioning
confidence: 98%
“…Clearly, its formation requires both considerable elongation, and also intricate coiling and packaging, since the epididymal tube is about 100 times longer than the body. Elongation of the WD appears to be a result of cell proliferation and cell rearrangements [reviewed in Hinton et al, 2011]. This process is clearly mediated by androgens, since it fails in the absence of AR, or androgen signalling, but the downstream events and molecular and cellular interactions responsible are still unclear.…”
Section: Forming the Epididymismentioning
confidence: 99%