How Does an Ectodomain of Membrane-Associated Proteins Stand Upright and Exert Robust Signal?

Lankipalli, Swetha; Ramagopal, U.A.

doi:10.2139/ssrn.3751762

SSRN Journal

2020

DOI: 10.2139/ssrn.3751762

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How Does an Ectodomain of Membrane-Associated Proteins Stand Upright and Exert Robust Signal?

Swetha Lankipalli

U.A. Ramagopal

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2021

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Cited by 2 publications

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“…Such cis association has been proposed for some of the adhesion proteins and other proteins involved in immune signaling. [38][39][40] In particular, B7-2 being a monomer in solution, either cis oligomerization or clustering appear to support its "upright" orientation and effective function on the cell surface.…”

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Cryptic association of B7‐2 molecules and its implication for clustering

et al. 2021

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T‐cell co‐stimulation through CD28/CTLA4:B7‐1/B7‐2 axis is one of the extensively studied pathways that resulted in the discovery of several FDA‐approved drugs for autoimmunity and cancer. However, many aspects of the signaling mechanism remain elusive, including oligomeric association and clustering of B7‐2 on the cell surface. Here, we describe the structure of the IgV domain of B7‐2 and its cryptic association into 1D arrays that appear to represent the pre‐signaling state of B7‐2 on the cell membrane. Super‐resolution microscopy experiments on heterologous cells expressing B7‐2 and B7‐1 suggest, B7‐2 form relatively elongated and larger clusters compared to B7‐1. The sequence and structural comparison of other B7 family members, B7‐1:CTLA4 and B7‐2:CTLA‐4 complex structures, support our view that the observed B7‐2 1D zipper array is physiologically important. This observed 1D zipper‐like array also provides an explanation for its clustering, and upright orientation on the cell surface, and avoidance of spurious signaling.

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Cryptic association of B7‐2 molecules and its implication for clustering

et al. 2021

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A structural perspective on the design of decoy immune modulators

Lankipalli

Ramagopal

2021

Pharmacological Research

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How Does an Ectodomain of Membrane-Associated Proteins Stand Upright and Exert Robust Signal?

Cited by 2 publications

References 58 publications

Cryptic association of B7‐2 molecules and its implication for clustering

Cryptic association of B7‐2 molecules and its implication for clustering

A structural perspective on the design of decoy immune modulators

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