How Does Arsenic Contamination of Groundwater Causes Severity and Health Hazard in Bangladesh

Chowdhury, M. A. I.; Uddin, M. T.; Ahmed, Mushfique; Ali, Mohammad; Uddin, Salah

doi:10.3923/jas.2006.1275.1286

Cited by 15 publications

(4 citation statements)

References 28 publications

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“…Arsenite intoxication limits ATP production (Hughes et al 2011), while potentiating oxidative stress which readily leads to cellular dysfunction (Rana et al 2011). While the mechanism of arsenic toxicity remains limited, current treatment and preventive measures for arsenic intoxica-tion are still elusive (Chowdhury et al 2006). Therefore, identifying the cellular factors that contribute to modulate the liver response to arsenicals is central to understanding their toxicology.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Adeyemi

Meyakno²,

Akanji³

2017

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Study determined the influence of the inhibition of Kupffer cell functions by GdCl3 in arsenic intoxication. Twenty-four Wistar rats weighing between 150 and 160 g were randomly assigned into four groups. Group 1 received sodium arsenite (1.5 mg/kg b.w.) once a day, Group 2 received GdCl3 (2 mg/kg b.w.) once, 24 hours before commencing the arsenite (1.5 mg/kg b.w.) treatment. Group 3 received GdCl3 (2 mg/kg b.w.) once and subsequently given distilled water. Group 4 received distilled water only. The treatments were daily by oral gavage and lasted for 28 days. Animals were euthanized 24 hours after the last treatment. Arsenic exposure elevated the activities of rat plasma AST, ALT, ALP and γ-GT, indicative of liver injury. Arsenic exposure in rat lowered GSH concentration but potentiated inflammation and oxidative stress evidenced in the raised levels of MPO, NO and MDA. Rats with arsenic exposure were predisposed to atherosclerosis, lowering the HDL-C but elevated the LDL-C concentration. The histopathological assessment showed degenerating cellular lesion caused by arsenic. However, the inhibition of Kupffer cell functions by GdCl3 suppressed arsenic intoxication improving the liver function indices, oxidative stress status, lipid profile, neutrophilic inflammation and ultimately restored the cellular architecture. Data suggest that specific inhibition of Kupffer cells by GdCl3 protected against arsenic intoxication.

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Section: Introductionmentioning

confidence: 99%

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Adeyemi

Meyakno²,

Akanji³

2017

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“…In Bangladesh, results indicated at least a doubling of lifetime mortality risk from liver, bladder, and lung cancers (229.6 vs. 103.5 per 100 000 population) owing to arsenic in drinking water (Chen and Ahsan, 2004). This has an enormous impact since it is estimated that of the 140 million inhabitants of Bangladesh, more than 100 million are at risk of arsenic poisoning (Chowdhury et al, 2006). The cancer risks from arsenic in drinking water were assessed by Smith et al (1992) for the USA situation.…”

Section: Source Of Arsenicmentioning

confidence: 99%

“…The large well-to-well variability in arsenic concentrations bears the consequence that in the villages all wells need to be tested. It is estimated that 37 to 100 million people are at risk of drinking arsenic-contaminated drinking water (WHO, 2001;Chowdhury et al, 2006). In a bulletin (Smith et al, 2000), the World Health Organization reports that it is estimated that long-term exposure to arsenic in groundwater, at concentrations over 500 µg L −1 , causes death in 1 in 10 adults (including lung, bladder and skin cancers).…”

Section: Introductionmentioning

confidence: 99%

Arsenic in drinking water: not just a problem for Bangladesh

Halem¹,

Bakker²,

Amy³

et al. 2009

Preprint

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Abstract. For more than a decade it has been known that shallow tube wells in Bangladesh are frequently contaminated with arsenic concentrations at a level that is harmful to human health. By now it is becoming clear that a disaster of an unheard magnitude is going on: the World Health Organization fears that in the near future 1 in every 10 adult deaths in Bangladesh will be caused by arsenic-related cancers. Other studies show that problems with arsenic in groundwater/drinking water occur in many more countries worldwide, such as in the USA and China. In Europe the focus on arsenic problems is confined to countries with high arsenic levels in their groundwater, such as Romania, Hungary and Italy. In most other European countries, the naturally occurring arsenic concentrations are lower than the drinking water standard of 10 μg L−1. However, from the literature review presented in this paper, it may also be concluded that using the European standard, health risks cannot be excluded. It is therefore recommended that the current arsenic standard be reconsidered.

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“…Diseases caused by drinking arsenic-contaminated groundwater have now become a burden for family and society (Chowdhury et al 2006). Social inability, social discrimination and stigma (Chowdhury et al 2006) give birth to psychological problems like anxiety, anger, sadness, depression and jealousy (DeWall & Anderson 2011).…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

Mental health in arsenic-induced cancer: a study from middle Gangetic plain of Bihar, India

Kumar

Ghosh

Bharti

2022

Journal of Water, Sanitation and Hygiene for Development

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The health impact of groundwater arsenic contamination shall remain partially understood while its psychological aspects are not studied. So, this correlational survey research explored mental health as a function of perceived social support in arsenic-induced cancer (AIC), which is highly prevalent in the middle Gangetic plain. Mental health inventory and multidimensional scale of perceived social support were used to assess mental health (MH) and perceived social support (PSS) respectively in 77 AIC patients. Findings show significant impact of PSS on MH in the arsenic-affected regions. PSS from significant others have strong impact on overall MH. Perception of reality was predicted by PSS from family while global PSS predicted two dimensions of MH, i.e. positive self-evaluation and environmental mastery. This baseline study suggests that global PSS and that from family and significant others is important and has a strong impact on MH of this population. These findings would help early identification and/or psychological intervention (from non-government organizations, oncology social workers/researchers, and policy makers) to promote better health and well-being in this arsenic-affected population.

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How Does Arsenic Contamination of Groundwater Causes Severity and Health Hazard in Bangladesh

Cited by 15 publications

References 28 publications

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Arsenic in drinking water: not just a problem for Bangladesh

Mental health in arsenic-induced cancer: a study from middle Gangetic plain of Bihar, India

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