How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume?

Korzeniowska, Katarzyna; Ramotowska, Anna; Szypowska, Agnieszka; Szadkowska, Agnieszka; Fendler, Wojciech; Kalina-Faska, Barbara; Młynarski, Wojciech; Jarosz-Chobot, Przemysława; Myśliwiec, Małgorzata

doi:10.1515/jpem-2013-0455

Cited by 9 publications

(13 citation statements)

References 2 publications

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“…This is in agreement with previous studies that found no correlation between single and/or combined diabetes Ab positivity and diabetes control where some pancreatic function was preserved [39,40,46]. However, interestingly it was proved recently, that autoimmune thyroiditis accompanying T1DM is associated with worse glycemic control and lipid profile [47].…”

Section: Discussionsupporting

confidence: 93%

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Głowińska‐Olszewska

Michalak

Łuczyński

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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Background: The aim of this study was to assess the prevalence of diabetes and other organ-specific autoantibodies (Ab) associated with various autoimmune conditions, in Polish children with type 1 diabetes mellitus (T1DM). Methods: In this study 114 patients, aged 13.4 years, with mean diabetes duration 5.2 years were included. Ab to islet cell antigens: glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA-2), zinc transporter 8 (ZnT8), together with thyroid peroxidase Ab (TPO Ab), thyroglobulin Ab (Tg Ab), tissue transglutaminase Ab (tTG Ab) and 21-hydroxylase Ab (21-OH Ab) were measured. Results: The prevalence of at least one diabetes associated Ab was found in 87%, with the highest prevalence of 64% for ZnT8 Ab. In patients with disease duration < 5 years, at least one antibody was present in 90%, the most prevalent was ZnT8 Ab (72%). In patients with duration > 10 years, 50% had at least one antibody. The prevalence of other than islet cell autoimmunity was high (34%). Thyroid Ab were detected in 26% patients, 42% in girls vs. 8% in boys, p < 0.001. tTG Ab were found in 11% patients, with a greater prevalence in children with early onset (p = 0.01). 21-OH Ab were found in 2.6% T1DM patients.

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Section: Discussionsupporting

confidence: 93%

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Głowińska‐Olszewska

Michalak

Łuczyński

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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“…Polycystic ovary syndrome (PCOS) is the most common endocrine disease among women in reproductive age. It manifests mainly menstrual disorders and impaired fertility, clinical and biochemical hyperandrogenism, and characteristic polycystic image of ovaries in ultrasound scan [75]. Insulin resistance and elevated insulin PRACE POGLĄDOWE levels may be an important element in the pathogenesis of PCOS.…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

“…The prevalence of metabolic syndrome in women with PCOS depends not only on genetic but also on behavioural factors. Weight loss by lowering insulin levels causes a decrease in androgen production and may lead to the return of ovulation [75]. On the other hand, the therapy with metformin appears to be effective in inducing ovulation and returning impaired fertility in PCOS.…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

“…Zespół policystycznych jajników (PCOS, polycystic ovary syndrome) jest jedną z najczęstszych endokrynopatii wśród kobiet w wieku reprodukcyjnym. Manifestuje się głównie zaburzeniami miesiączkowania i upośledzoną płodnością, klinicznym lub biochemicznym hiperandrogenizmem i charakterystycznym obrazem jajników o policystycznym wyglądzie [75]. Insulinooporność i podwyższone stężenie insuliny mogą być istotnym elementem w patogenezie PCOS.…”

Section: Prace Poglądoweunclassified

“…nego u kobiet z PCOS zależy nie tylko od czynników genetycznych, ale również behewioralnych. Redukcja masy ciała poprzez obniżenie insulinemii powoduje spadek produkcji androgenów i może doprowadzić do powrotu owulacji [75]. Z drugiej strony zastosowanie metforminy, leku uwrażliwiającego na insulinę wydaje się być skuteczne w indukcji owulacji i powrotu zaburzonej płodności w PCOS.…”

Section: Prace Poglądoweunclassified

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Insulinooporność w chorobach endokrynnych — sposoby terapii

Rogowicz-Frontczak

Majchrzak²,

Zozulińska‐Ziółkiewicz

2017

Endokrynologia Polska

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Changes in sensitivity to insulin occur in the course of a number of endocrine disorders. Most of the hormones through their antagonistic action to insulin lead to increased hepatic glucose output and its decreased utilisation in peripheral tissues. Carbohydrate disorders observed in endocrine diseases result from the phenomenon of insulin resistance, and in some cases also a reduction in insulin secretion is present. Abnormalities of glucose metabolism are observed in acromegaly, but also in growth hormone deficiency, hypercortisolism in the course of Cushing's syndrome, hyper- or hypothyroidism, primary hyperparathyroidism, aldosteronism, pheochromocytoma, congenital hypertrophy of the adrenal glands, polycystic ovaries syndrome, hypogonadism, or other hormonally active neuroendocrine tumours. They are of a secondary nature in relation to impaired hormonal balance. Hyperglycaemia is therefore often reversible, and the most effective method of treatment of impaired insulin sensitivity is successful therapy of specific endocrinopathies. Insulin sensitisers, also with a good effect, are used. Most experiences to date can be attributed to metformin therapy. Attempts have been made at treatment with other agents that are also effective in reducing insulin resistance as incretins or glitazones. In the presented paper, the authors reviewed endocrine diseases in which there is a clinically significant change in insulin sensitivity. Moreover, methods of therapy of concomitant disturbed glucose metabolism were presented.

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Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis

Jonsdottir

Larsson

Carlsson

et al. 2016

The Journal of Clinical Endocrinology & Metabolism

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How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume?

Abstract: AIT accompanying DM1 is associated with worse glycemic control and lipid profile as well as a lower daily insulin requirement. The female gender is more likely to develop AIT and hypothyroidism.

Cited by 9 publications

References 2 publications

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Insulinooporność w chorobach endokrynnych — sposoby terapii

Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis

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