Spain is one of the leading wine-producing and -exporting countries and has traditionally been dominant in trade and world production in the sector. In an increasingly changing context, in which worldwide wine exports are growing exponentially, it is essential to study their impact on climate change as the transport of goods generates a significant volume of greenhouse gas emissions. The aim of this work, then, was to analyse the variation in the carbon footprint generated by Spanish wine exports between 2011 and 2016. To this end, a multi-regional input–output (MRIO) model was used, showing that the emissions associated with wine operations have increased less than exports, which might suggest that sustainable growth has been included as a goal in the wine supply chain. The methodology used has the advantage of allowing the calculation of direct and indirect emissions. At the same time, the results can provide relevant information to practitioners and policymakers due to the expected evolution of European environmental regulations and trades, in terms of carbon footprint.