How does exercise affect energy metabolism? An in silico approach for cardiac muscle

Yalçınkaya, Bahar Hazal; Genç, Seda; Yılmaz, Bayram; Özilgen, Mustafa

doi:10.1016/j.heliyon.2023.e17164

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…The body adjusts its physiological functions to accommodate the increased demand for energy and oxygen during physical activity. These changes include increased body temperature, respiration rate, heart rate, and blood pressure, while at a molecular level, hydrolysis and recovery of adenosine triphosphate (ATP) are intensified [18].…”

Section: Body Functions During Physical Exercisementioning

confidence: 99%

“…The energy required for muscle contractions, enabling movement, is produced through ATP hydrolysis in muscle mitochondria. For aerobic exertion, this includes the following metabolic pathways of cellular respiration: glycolysis, pyruvate oxidation, the tricarboxylic acid cycle, and oxidative phosphorylation [18]. Anaerobic bouts of exercise involve oxygen-free mechanisms such as anaerobic glycolysis and the phosphagen system (phosphocreatine utilization) based on muscle stores.…”

Section: Energy Metabolismmentioning

confidence: 99%

“…An instant source of energy is produced when glycogenolysis converts glycogen stored in muscle and liver cells into glucose. When the glucose concentration is too low (consumption of glycogen stores and lack of current supply of simple sugars), ATP is produced using the β-oxidation of fatty acids [18]. However, specific alterations must be considered in relation to exercise intensity and diet.…”

Section: Energy Resourcesmentioning

confidence: 99%

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The Current State of Knowledge Regarding the Genetic Predisposition to Sports and Its Health Implications in the Context of the Redox Balance, Especially Antioxidant Capacity

Sutkowy,

Modrzejewska,

Porzych

et al. 2024

IJMS

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The significance of physical activity in sports is self-evident. However, its importance is becoming increasingly apparent in the context of public health. The constant desire to improve health and performance suggests looking at genetic predispositions. The knowledge of genes related to physical performance can be utilized initially in the training of athletes to assign them to the appropriate sport. In the field of medicine, this knowledge may be more effectively utilized in the prevention and treatment of cardiometabolic diseases. Physical exertion engages the entire organism, and at a basic physiological level, the organism’s responses are primarily related to oxidant and antioxidant reactions due to intensified cellular respiration. Therefore, the modifications involve the body adjusting to the stresses, especially oxidative stress. The consequence of regular exercise is primarily an increase in antioxidant capacity. Among the genes considered, those that promote oxidative processes dominate, as they are associated with energy production during exercise. What is missing, however, is a look at the other side of the coin, which, in this case, is antioxidant processes and the genes associated with them. It has been demonstrated that antioxidant genes associated with increased physical performance do not always result in increased antioxidant capacity. Nevertheless, it seems that maintaining the oxidant–antioxidant balance is the most important thing in this regard.

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Section: Body Functions During Physical Exercisementioning

confidence: 99%

Section: Energy Metabolismmentioning

confidence: 99%

Section: Energy Resourcesmentioning

confidence: 99%

See 1 more Smart Citation

The Current State of Knowledge Regarding the Genetic Predisposition to Sports and Its Health Implications in the Context of the Redox Balance, Especially Antioxidant Capacity

Sutkowy,

Modrzejewska,

Porzych

et al. 2024

IJMS

View full text Add to dashboard Cite

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Assessment of entropy accumulation in human subjects when exposed to low energy availability

Yildiz,

Köhler,

Wasserfurth

et al. 2024

Heliyon

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Thermodynamic Assessment of the Causes of the Death of the People Under the Debris in an Earthquake

Aslan,

Olgun,

Yavuz

et al. 2025

Disaster med. public health prep.

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Mortality rate of the crush victims in the Marmara earthquake of August 1999 was compared with the conclusions arrived after making thermodynamic assessment of the data acquired in the previous earthquakes. Entropic age concept was found very helpful while assessing the data. Mortality rate in the age group of 0-9 years old crush victims was 0 because the basal metabolic rate (BMR) of these children was low. The earthquake happened at 3:03 a.m. in the morning and it was probably at the coldest time of the day; therefore, the victims were losing sufficient heat to avoid hyperpraxia, where body temperature reaches to 40°C or above. As the population and the age of the victims increase more people died and the survival rate decreased. The highest mortality rate was in the 60+ age group. According to the entropic age concept, these group of victims had already accumulated a lot of entropy (e.g., heath problems) in their bodies in previous stages of their lives; therefore, they were more prone to death.

show abstract

How does exercise affect energy metabolism? An in silico approach for cardiac muscle

Cited by 3 publications

References 40 publications

The Current State of Knowledge Regarding the Genetic Predisposition to Sports and Its Health Implications in the Context of the Redox Balance, Especially Antioxidant Capacity

The Current State of Knowledge Regarding the Genetic Predisposition to Sports and Its Health Implications in the Context of the Redox Balance, Especially Antioxidant Capacity

Assessment of entropy accumulation in human subjects when exposed to low energy availability

Thermodynamic Assessment of the Causes of the Death of the People Under the Debris in an Earthquake

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