How does the brain change in chronic migraine? Developing disease biomarkers

Pozo‐Rosich, Patricia; Pascual, Julio; Schwedt, Todd J.

doi:10.1177/0333102420974359

Cited by 28 publications

(30 citation statements)

References 111 publications

(127 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as mentioned, the plasma concentration of CGRP is elevated during migraine attacks in association with neurogenic inflammation [ 22 ], and due to TMV sensitization, it drains CGRP from the brain. Indeed, CGRP levels in peripheral plasma, saliva, and cerebrospinal fluid are increased during interictal, headache-free periods in patients with chronic migraine [ 23 ]. Thus, exposure of systemic circulation to CGRP is more pronounced in migraineurs.…”

Section: Discussionmentioning

confidence: 99%

The Responses to CGRP in the Territory of the Posterior Cerebral Artery in Migraine

Visočnik

Zaletel

Zupan

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Calcitonin gene-related peptide (CGRP) is important in trigeminovascular (TMV) sensitization with neurogenic inflammation which might be involved in CGRP-induced headache (CGRP-IH). Distribution of white matter lesions, migraine aura, and functional neuroimaging indicate that posterior circulation is especially exposed to TMV sensitization. The transcranial Doppler (TCD) is able to detect changes in the posterior cerebral artery (PCA) during CGRP stimulation. Thus, we studied CGRP-induced hemodynamic changes in PCA and frequency of CGRP-IH. Twenty healthy subjects and 20 patients with migraine participated in our study. TCD was used to monitor mean arterial velocity in posterior cerebral artery (vmPCA). Simultaneously, end-tidal carbon dioxide (Et-CO2), mean arterial pressure (MAP), and heart rate (HR) were measured. During the experiment, we monitored the frequency of CGRP-IH. We determined the values of vmPCA, Et-CO2, MAP, and HR and calculate the response of vmPCA, Et-CO2, MAP, and HR to CGRP. To test the differences and relationships, statistical methods were applied using SSPS. We found significant decrease in vmPCA in migraine and control groups and found the vmPCA response to be significantly lower in migraine ( p = 0.018 ). Et-CO2 decreases in both groups, and it is significantly lower in migraine ( p < 0.001 ). MAP is significantly higher in migraine ( p = 0.001 ), while HR is not significantly higher in migraine ( p = 0.570 ). CGRP-IH is significantly associated with vmPCA responses ( p = 0.003 ) and migraine ( p < 0.001 ). We concluded that hemodynamic changes in PCA are significantly related to CGRP-IH. The TMV sensitization might be pronounced in posterior circulation explaining clinical and morphologic issues in migraine.

show abstract

Section: Discussionmentioning

confidence: 99%

The Responses to CGRP in the Territory of the Posterior Cerebral Artery in Migraine

Visočnik

Zaletel

Zupan

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…However, as mentioned the plasma concentration of CGRP is elevated during migraine attacks in association with neurogenic in ammation ( 21) and due to TMV sensitization it drains CGRP from the brain. Indeed, CGRP levels in peripheral plasma, saliva and cerebrospinal uid are increased during interictal, headache-free periods in patients with chronic migraine (22). Thus, exposure of systemic circulation to CGRP is more pronounced in migraineurs.…”

Section: Discussionmentioning

confidence: 99%

The Responses to CGRP in The Teritory of the Posterior Cerebral Artery in Migraine

Visočnik

Zaletel²,

Žvan³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Calcitonin gene-related peptide (CGRP) is important in trigeminovascular (TMV) sensitization with neurogenic inflammation which might be evolved in CGRP induced headache (CGRP-IH). Distribution of white matter lesions, migraine aura and functional neuroimaging indicate that posterior circulation is especially exposed to TMV sensitization. The transcranial doppler (TCD) is able to detect changes in posterior cerebral artery (PCA) during CGRP stimulation. Thus, we studied CGRP induced hemodynamic changes in PCA and CGRP-IH using TCD. Methods Twenty healthy subjects and 20 patients with migraine participated in our study. TCD was used to monitored mean arterial velocity in posterior cerebral artery (vm PCA). Simultaneously End tidal carbone dioxide (Et-CO2), mean arterial pressure (MAP) and heart rate (HR) were measured. During experiment we monitored the frequency of CGRP-IH. We determined the values of vmPCA, Et-CO2, MAP and HR and calculate response of vmPCA, Et-CO2, MAP and HR to CGRP. To test the differences and relationships statistical methods were applied using SSPS. Results We found significant decrease of vmPCA in migraine and control groups and found the vmPCA response to be significant lower in migraine (p = 0.018). Et-CO2 decreases in both groups and it is significantly lower in migraine (p > < 0.001). MAP is significantly higher in migraine(p = 0.001), while HR is not significantly higher in migraine (p = 0.570). CGRP-IH is significantly associated with vmPCA responses (p = 0.003) and migraine (p < 0.001). Conclusion We concluded that hemodynamic changes in PCA are significantly related to CGRP-IH. The TMV sensitization might be pronounced in posterior circulation explaining clinical and morphologic issues in migraine.

show abstract

“…Although this work may seem to be far from migraine pathogenesis, many works, especially those of Borkum, consider migraine as a neuroprotective response against oxidative stress in the brain [ 123 , 124 , 125 , 126 ]. Although, in general, migraine is not classified as a typical neurodegenerative disease, several reports associate migraine with injuries in the brain resulting from degenerative processes in neurons and other brain cells [ 127 , 128 ]. Therefore, both lncRNA and miRNA may regulate CGRP to protect against neurodegenerative changes in the brain, which can be related to migraine.…”

Section: Epigenetic Connections Of Cgrpmentioning

confidence: 99%

Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine

Fila

Sobczuk

Pawłowska

et al. 2022

IJMS

View full text Add to dashboard Cite

The calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of several pain-related syndromes, including migraine. Targeting CGRP and its receptor by their antagonists and antibodies was a breakthrough in migraine therapy, but the need to improve efficacy and limit the side effects of these drugs justify further studies on the regulation of CGRP in migraine. The expression of the CGRP encoding gene, CALCA, is modulated by epigenetic modifications, including the DNA methylation, histone modification, and effects of micro RNAs (miRNAs), circular RNAs, and long-coding RNAs (lncRNAs). On the other hand, CGRP can change the epigenetic profile of neuronal and glial cells. The promoter of the CALCA gene has two CpG islands that may be specifically methylated in migraine patients. DNA methylation and lncRNAs were shown to play a role in the cell-specific alternative splicing of the CALCA primary transcript. CGRP may be involved in changes in neural cytoarchitecture that are controlled by histone deacetylase 6 (HDAC6) and can be related to migraine. Inhibition of HDAC6 results in reduced cortical-spreading depression and a blockade of the CGRP receptor. CGRP levels are associated with the expression of several miRNAs in plasma, making them useful peripheral markers of migraine. The fundamental role of CGRP in inflammatory pain transmission may be epigenetically regulated. In conclusion, epigenetic connections of CGRP should be further explored for efficient and safe antimigraine therapy.

show abstract

How does the brain change in chronic migraine? Developing disease biomarkers

Cited by 28 publications

References 111 publications

The Responses to CGRP in the Territory of the Posterior Cerebral Artery in Migraine

The Responses to CGRP in the Territory of the Posterior Cerebral Artery in Migraine

The Responses to CGRP in The Teritory of the Posterior Cerebral Artery in Migraine

Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine

Contact Info

Product

Resources

About