How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Birder, Lori A.; Ruggieri, Michael R.; Takeda, Masayuki; Koeveringe, Gommert van; Veltkamp, Stephan A.; Korstanje, Cees; Parsons, Brian A.; Fry, Christopher

doi:10.1002/nau.22195

Cited by 81 publications

(96 citation statements)

References 108 publications

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“…Sensory function impairment due to stones or neoplasms can cause changes to the urothelium resulting in bladder overactivity and urge incontinence, or in underactive bladder in case of outlet obstruction [25]. Similarly, an urothelial disfunction could be supposed to be linked with the development of bladder cancer.…”

Section: Bladder Cancermentioning

confidence: 99%

Bladder Cancer and Urothelial Impairment: The Role of TRPV1 as Potential Drug Target

Mistretta

Buffi

Lughezzani

et al. 2014

BioMed Research International

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Urothelium, in addition to its primary function of barrier, is now understood to act as a complex system of cell communication that exhibits specialized sensory properties in the regulation of physiological or pathological stimuli. Furthermore, it has been hypothesized that bladder inflammation and neoplastic cell growth, the two most representative pathological conditions of the lower urinary tract, may arise from a primary defective urothelial lining. Transient receptor potential vanilloid channel 1 (TRPV1), a receptor widely distributed in lower urinary tract structures and involved in the physiological micturition reflex, was described to have a pathophysiological role in inflammatory conditions and in the genesis and development of urothelial cancer. In our opinion new compounds, such as curcumin, the major component of turmeric Curcuma longa, reported to potentiate the effects of the chemotherapeutic agents used in the management of recurrent urothelial cancer in vitro and also identified as one of several compounds to own the vanillyl structure required to work like a TRPV1 agonist, could be thought as complementary in the clinical management of both the recurrences and the inflammatory effects caused by the endoscopic resection or intravesical chemotherapy administration or could be combined with adjuvant agents to potentiate their antitumoral effect.

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Section: Bladder Cancermentioning

confidence: 99%

Bladder Cancer and Urothelial Impairment: The Role of TRPV1 as Potential Drug Target

Mistretta

Buffi

Lughezzani

et al. 2014

BioMed Research International

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“…It is likely that there are more factors contributing to CAUTI than fluid intake which could be related to a wide range of individual differences, such as changes which could have taken place in the bladder mucosa (urothelium) due to persistent CAUTI episodes or other factors. Physiological research related to urinary tract infection is promising, particularly in the study of biomarkers and urothelial defense mechanisms (Birder et al, 2012), but much more research will be required for a full understanding of the complex issues of CAUTI in persons with long-term indwelling urinary catheters.…”

Section: Discussionmentioning

confidence: 99%

Testing a Model of Self-Management of Fluid Intake in Community-Residing Long-term Indwelling Urinary Catheter Users

Wilde¹,

Crean²,

McMahon

et al. 2016

Nursing Research

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Background Urinary tract infection and blockage are serious and recurrent challenges for people with long-term indwelling catheters, and these catheter problems cause worry and anxiety when they disrupt normal daily activities. Objectives The goal was to determine whether urinary catheter-related self-management behaviors focusing on fluid intake would mediate fluid intake related self-efficacy toward decreasing catheter-associated urinary tract infection (CAUTI) and/or catheter blockage. Method The sample involved data collected from 180 adult community-living, long-term indwelling urinary catheter users. The authors tested a model of fluid intake self-management (F-SMG) related to fluid intake self-efficacy (F-SE) for key outcomes of CAUTI and blockage. To account for the large number of zeros in both outcomes, a zero inflated negative binomial (ZINB) structural equation model was tested. Results Structurally, F-SE was positively associated with F-SMG, suggesting that higher F-SE predicts more (higher) F-SMG; however, F-SMG was not associated with either the frequency of CAUTI’s or the presence or absence of CAUTI. F-SE was positively related to F-SMG and F-SMG predicted less frequency of catheter blockage, but neither F-SE nor F-SMG predicted the presence or absence of blockage. Discussion Further research is needed to better understand determinants of CAUTI in long-term catheter users and factors which might influence or prevent its occurrence. Increased confidence (self-efficacy) and self-management behaviors to promote fluid intake could be of value in long-term urinary catheter users to decrease catheter blockage.

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“…The pathophysiology of underactive bladder may involve neurogenic, myogenic, and bladder outlet pathologies [1]. Recent studies also reveal that urothelial dysfunction of the urinary bladder may be associated with impaired bladder sensation as well as impaired detrusor contractility [2]. …”

Section: Introductionmentioning

confidence: 99%

Video-urodynamic characteristics of non-neurogenic, idiopathic underactive bladder in men – A comparison of men with normal tracing and bladder outlet obstruction

Jiang

Kuo

2017

PLoS ONE

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ObjectiveUnderactive bladder is frequently encountered in elderly patients. It may result from detrusor underactivity (DU) or low detrusor contractility due to a urethral sphincter inhibitory effect. This study analyzed the video-urodynamic study (VUDS) characteristics of patients with underactive bladder in a large cohort of men with lower urinary tract symptoms (LUTS).MethodsMale patients with LUTS who had failed the initial treatment were consecutively enrolled. All patients underwent detailed urological investigations including prostate measurement, free uroflowmetry, post-void residual volume (PVR) measurement, cystoscopy and VUDS. The VUDS characteristics of the men with underactive bladder were analyzed and compared with those of men with bladder outlet obstruction and normal tracing.ResultsA total of 1329 men who underwent VUDS were included in this retrospective analysis. After VUDS, the final diagnosis was DU in 165 patients, poor relaxation of external sphincter (PRES) in 525, bladder outlet obstruction in 501, and normal tracing in 138. VUDS findings in DU patients showed a slowly increased detrusor pressure, intermittent detrusor contractions, or early decline of detrusor contraction, resulting in a low maximum flow rate (Qmax), and large PVR. In comparison with the PRES groups, DU patients were older, had reduced bladder sensation, lower detrusor pressure (Pdet), lower Qmax, larger PVR volume, and lower voiding efficiency. Patients with urodynamic PRES also had low-pressure–low-flow tracings, but their bladder sensation was similar to that with normal tracing. DU patients with very low Pdet also had low detrusor tonicity, and more medical co-morbidities than the other groups did.ConclusionIdiopathic underactive bladder in elderly men could be attributed to urodynamic DU and PRES. DU is associated with old age, reduced bladder sensation, low voiding efficiency, and medical co-morbidities.

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How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Cited by 81 publications

References 108 publications

Bladder Cancer and Urothelial Impairment: The Role of TRPV1 as Potential Drug Target

Bladder Cancer and Urothelial Impairment: The Role of TRPV1 as Potential Drug Target

Testing a Model of Self-Management of Fluid Intake in Community-Residing Long-term Indwelling Urinary Catheter Users

Video-urodynamic characteristics of non-neurogenic, idiopathic underactive bladder in men – A comparison of men with normal tracing and bladder outlet obstruction

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