How Does Tinidazole Compare with Metronidazole?

Bakshi, Jyoti; Ghiara, J. M.; Nanivadekar, A. S.

doi:10.2165/00003495-197800151-00008

Cited by 27 publications

(7 citation statements)

References 7 publications

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“…Only 11 trials had at least one blinded outcome measurement (Al-Waili & Hasan 1992;Bakshi et al 1978;Cimerman et al 1988;Gupta et al 1989;Hall 1993;Jokipii & Jokipii 1982;Kalayci 1995;Leary et al 1974;Ockhuysen et al 1989;Palomino et al 1970;Speelman 1985).…”

Section: Internal Validitymentioning

confidence: 99%

“…Seven trials compared the standard tinidazole regimen (either 1.5 or 2 g as a single dose) with other single-dose therapies (Bakshi et al 1978;Jokipii & Jokipii 1982;Gazder & Banerjee 1977;Kyronseppa & Petterson 1981 in symptomatic patients;Suntornpoch & Chavalittamrong 1981;Speelman 1985a;Nigam et al 1991 in symptomatic and asymptomatic patients). Considering parasitological cure, tinidazole is more effective than other singledose therapies (odds ratio 5.5, 95% CI 3.7-8.25) ( Figure 4).…”

Section: Standard Single-dose (Tinidazole) Versus Other Single-dose Tmentioning

confidence: 99%

“…Heterogeneity between trials is not significant (P=0.24). Five trials (Bakshi et al 1978;Gazder & Banerjee 1977;Kyronseppa & Petterson 1981;Nigam et al 1991;Suntornpoch & Chavalittamrong 1981) used clinical cure (relief of symptoms and negative stools) as the outcome parameter. Tinidazole is more effective (odds ratio 5.43, CI 3.64-8.10).…”

Section: Standard Single-dose (Tinidazole) Versus Other Single-dose Tmentioning

confidence: 99%

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A systematic review on the treatment of giardiasis

Zaat¹,

Mank

Assendelft³

1997

Tropical Med Int Health

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SummaryTo assess the efficacy of treatment of parasitological excretion of cysts and trophozoites and symptoms of patients with giardiasis, a systematic review of published randomized clinicial trials was conducted through extensive searches in Medline, Embase and Current Contents from 1966 till 1996 as well as manual reviews of 28 journals. The methodological quality of all trials was assessed by guidelines of the Cochrane Collaboration. Thirty-one trials were included, only one of which had no serious methodological flaws. The mean score of parasitological examination was 4.8 out of a possible 15. There was a considerable effect in cure rate of treatment versus placebo (odds 9.3, 95%CI 4.69-18.4), but all 3 trials in this comparison had serious flaws. Metronidazole treatment over more than 3 days seems to achieve a better parasitological cure rate than other long treatment courses (pooled odds 2.6, 95% 1.7-3.8), but trials are clinically and statistically heterogeneous. Single-dose therapy is as effective as longer treatment courses (pooled odds 0.67, 95% 0.31-1.44). Within the single-dose regimens tinidazole (2 g) reaches a higher parasitological cure rate than other short therapies (pooled odds 55, 95% CI 3.7-8.3) with relatively few side-effects. Placebo-controlled trials with parasitological and clincial outcomes are needed.

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Section: Internal Validitymentioning

confidence: 99%

Section: Standard Single-dose (Tinidazole) Versus Other Single-dose Tmentioning

confidence: 99%

Section: Standard Single-dose (Tinidazole) Versus Other Single-dose Tmentioning

confidence: 99%

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A systematic review on the treatment of giardiasis

Zaat¹,

Mank

Assendelft³

1997

Tropical Med Int Health

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“…The resultant outcome is the incomplete treatment and higher relapse rates with metronidazole therapy. 11 No renal or haematological side effect was reported from either of these drugs (15). Therefore because of less side effects and cost effective as well, tinidazole should be preferred on metronidazole (5).…”

Section: Discussionmentioning

confidence: 99%

“…The results revealed 88.3 % cure rate for tinidazole. While it was 46.7% for the group managed by metronidazole (15 (8,21).…”

mentioning

confidence: 93%

Meta-analysis for Searching Efficacy of Tinidazole and Metronidazole

Zafar¹,

Bukhari²,

Noor³

et al. 2017

Ulutas Med J

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Background: The 5-nitroimidazole antimicrobial agents are considered as the treatment of choice for managing the amebic, protozoal and anerobic infections since 1969. With the advancement in medical field certain preference of drugs in this group were given. Tinidazole is now considered as a better one as compared to metronidazole because of specific pharmacokinetic & pharmacodynamics properties.Objectives: To assess the frequency of preferred using tinidazole as compared to metronidazole for managing the amebic, protozoal infections and anerobic infections Methodology: This is a descriptive study with simple random sampling. Total 32 published studies in 04 decades were included in the study i.e 1978 -2017. The National and Internationally published data was gathered by using electronic measures and via certain search engines i.e pubmed researches, medscape, Pak medinet.com, google search, Euraopean, Canadian, Australlian, Centre for Disease Control (CDC), and World Health Organization (WHO) published guidelines. The published guidelines, original and review articles were taken for reference. Case reports, editorials & short communications were excluded.Results: This Meta-analysis review of various published researches showed that out of 69.2%(n=09) out of total 13 studies are in favour of preferring tinidazole. The frequency preference of metronidazole is 23% (n=23). Only one study (7%) showed the efficacy of both drugs is same.Conclusion: Tinidazole is a better option to manage anaerobic, amebic and protozoal infections.

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