Higher-order evidence can make an agent doubt the reliability of her reasoning. When this happens, it seems rational for the agent to adopt a cautious attitude towards her original conclusion, even in cases where the higher-order evidence is misleading and the agent's original reasons were actually perfectly good. One may think that recoiling to a cautious attitude in the face of misleading self-doubt involves a failure to properly respond to one's reasons. My aim is to show that this is not so. My proposal is that (misleading) higher-order evidence can undermine the agent's possession of her first-order reasons, constituting what I call a dispossessing defeater. After acquiring the higher-order evidence, the agent is no longer in a position to rely competently on the relevant first-order considerations as reasons for her original conclusion, so that such reasons stop being available to her (even if they remain as strong as in the absence of the higher-order evidence). In this way, an agent with misleading higher-order evidence can adopt a cautious stance towards her original conclusion, while properly responding to the set of reasons that she possesses-a set that is reduced due to the acquisition of higher-order dispossessing defeaters. Reasons Responsiveness (Permission): It is permissible for S to φ if and only if, on balance, S's possessed normative reasons sufficiently support φ-ing.