How dyspepsia led to the diagnosis of Morbus Crohn

Maertens, Anke; Persyn, Diederik; Moerkercke, Wouter Van

doi:10.1080/17843286.2019.1590497

Acta Clinica Belgica

2019

DOI: 10.1080/17843286.2019.1590497

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How dyspepsia led to the diagnosis of Morbus Crohn

Anke Maertens

Diederik Persyn²,

Wouter Van Moerkercke

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Cited by 3 publications

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“…33 In line with our results, Jocelyn A Silvester et al showed that FD occurs in 27% of patients with coeliac disease, which is relieved in most cases following the treatment of a gluten-free diet, 34 and A. Maertens et al reported a case about how dyspepsia led a diagnosis of Morbus Crohn. 35 Furthermore, our study confirms the investigation of Lebwohl et al about the association between H. pylori-negative CG with celiac disease. 36 Higher incidence of dyspeptic symptoms has also been observed in patients with Sjögren's syndrome, SLE, RA, and AI thyroiditis; 31,32,[37][38][39][40][41][42] however, our study could not confirm these associations.…”

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confidence: 91%

Dyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study

Zádori¹,

Németh²,

Frim³

et al. 2022

IJGM

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Introduction Dyspeptic symptoms are frequent in the general population, with a high socioeconomic burden. Helicobacter pylori ( H. pylori ) might be a possible etiological factor; however, it is also common in H. pylori negative gastritis. Clarification of the underlying aetiology might be beneficial to set up the optimal treatment strategy for dyspepsia and chronic gastritis (CG) itself. We aimed to assess the prevalence of dyspeptic symptoms in patients with H. pylori negative CG and explore autoimmunity’s possible role. Methods This retrospective study included data from patients with H. pylori negative CG. Exclusion criteria were (1) acute gastritis; (2) reactive gastropathy; (3) subjects without any serology testing results; (4) H. pylori positivity; (5) presence of atrophy, intestinal metaplasia (IM), gastroesophageal reflux disease (GERD), ulcer, or cancer. The following endpoints were assessed (1) the rate of dyspepsia-like symptoms; (2) association between dyspepsia and autoimmune disease-related seromarker positivity (AISP); (3) frequency of other symptoms in CG and its association with AISP; (4) location of the inflammation and its association with AISP. Results From a total of 285 patients, 175 were included in this study. Among these patients, 95 experienced dyspeptic symptoms (54.29%) and were associated more with AISP (p = 0.012), especially with celiac seropositivity (p = 0.045), anti-neutrophil cytoplasmic antibody (ANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA) positivity (p = 0.043). A significant association was not found with other tested autoimmune (AI)-related antibody positivity. Conclusion Positivity of seromarkers of autoimmune diseases in chronic gastritis may predispose to have dyspeptic symptoms and may be the causative factor behind some cases of uninvestigated dyspepsia. These data suggest that further prospective studies are needed to clarify whether screening for autoantibodies in patients with dyspepsia is cost-effective and helps the earlier diagnosis of autoimmune diseases.

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supporting

confidence: 91%

Dyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study

Zádori¹,

Németh²,

Frim³

et al. 2022

IJGM

View full text Add to dashboard Cite

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Combination of time-dependent polymer and inulin as a coating for sustained delivery of budesonide pellets aimed for use in IBD treatment

Soltani,

Kamali,

Akhgari

et al. 2023

Journal of Drug Delivery Science and Technology

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Correlation between dental symptoms and functional and clinical manifestations of Crohn's disease and ulcerative colitis

Yunusova,

Usmanova,

Lakman

et al. 2024

Perm Medical Journal

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Objective. To analyze the correlation between dental symptoms and clinical and functional manifestations of Crohn's disease (CD) and ulcerative colitis (UC). Materials and methods. A prospective, observational, longitudinal clinical study of 70 patients with verified inflammatory bowel diseases, i.e. Crohn's disease and ulcerative colitis, has been performed. For an in-depth assessment of the oral mucosa (OM) and red lip border (RLB) condition in patients with these systemic diseases, a complete dental examination has been carried out. The validated questionnaire "7´7" was used to objectify the symptoms of functional gastric dyspepsia. Results. In patients with the main clinical manifestations of the gastrointestinal tract impairments in CD and UC, extraintestinal dental manifestations in the form of meteorological cheilitis (16 and 9, respectively; p = 0.081), glossitis (15 and 11, respectively; p = 0.323), onset of recurrent aphthous stomatitis (17 and 11; p = 0.144), chronic mechanical trauma of oral mucosa (14 and 11; p = 0.455), and the presence of scalloped tongue (28 and 21, p = 0.068) were diagnosed. At the same time, the incidence of associated pathologies of OM and RLB was significantly higher in patients with CD (p0.05) than in patients with UC. Clinical examination of patients revealed predominance of flatulence symptoms in patients with CD and UC in 74.3 and 77.1 % of cases, respectively (р = 0.771). Patients with CD prevailed in the number of dyspeptic disorders and their variability but statistically significant differences were determined only for the symptom 'abdominal pain decreasing after bowel emptying'. The correlation between the frequency of dyspeptic disorders in patients and characteristic changes in the clinical state of RLB and OM was revealed. For the CD and UC groups Chuprov conjugacy coefficients were statistically significant (ChC=0.36, ChC=0.28 respectively). In patients with CD clinically apparent changes in the RLB and OM associated with various dyspeptic disorders were manifested more often than in patients with UC. Conclusion. The conducted study has shown that in patients with CD and UC there is a correlation between the frequency and severity of the main functional and clinical symptoms/syndromes (in the form of edema, hyperemia, pitting edema of the ОМ (in fact) and the RLB) and dyspeptic disorders, this correlation being stronger in Crohn's disease (p = 0.031 vs p = 0.046).

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How dyspepsia led to the diagnosis of Morbus Crohn

Cited by 3 publications

References 7 publications

Dyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study

Dyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study

Combination of time-dependent polymer and inulin as a coating for sustained delivery of budesonide pellets aimed for use in IBD treatment

Correlation between dental symptoms and functional and clinical manifestations of Crohn's disease and ulcerative colitis

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