How EBV Infects: The Tropism and Underlying Molecular Mechanism for Viral Infection

Bu, Guo‐Long; Xie, Chu; Kang, Yinfeng; Zeng, Mu‐Sheng; Sun, Cong

doi:10.3390/v14112372

Cited by 29 publications

(16 citation statements)

References 149 publications

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“…EBV has been thought to be associated with the development of several malignancies, such as Burkitt's lymphoma, Hodgkin's disease, and undifferentiated nasopharyngeal carcinoma. 179,180 Latent membrane protein 1 (LMP1), a key oncoprotein of EBV, is closely associated with various changes in EBV-associated cancers, including nasopharyngeal carcinoma (NPC). This protein might be responsible for apoptosis inhibition, cell proliferation, immortalization and transformation promotion, and metastasis of cancer cells.…”

Section: Rna-cleaving Dnazymes For Gene Therapymentioning

confidence: 99%

RNA-cleaving DNAzymes for accurate biosensing and gene therapy

Gao¹,

Liu²,

Huo³

et al. 2023

Nanoscale

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Section: Rna-cleaving Dnazymes For Gene Therapymentioning

confidence: 99%

RNA-cleaving DNAzymes for accurate biosensing and gene therapy

Gao¹,

Liu²,

Huo³

et al. 2023

Nanoscale

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“…In B cells, EBV infection is mediated by gp350 and gp42, while in epithelial cells, it is mediated by gHgL. 16 Additionally, gB serves as the primary fusogen indispensable for EBV entry into host cells. 17 Previous studies have demonstrated that antibodies targeting EBV glycoproteins possessed a potent ability to neutralize EBV infection in both B cells and epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

“…The mechanisms involved in EBV attachment to host cells are diverse and complex. In B cells, EBV infection is mediated by gp350 and gp42, while in epithelial cells, it is mediated by gHgL 16 . Additionally, gB serves as the primary fusogen indispensable for EBV entry into host cells 17 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum Epstein–Barr virus envelope glycoproteins antibodies and their association with systemic autoimmune diseases

Li,

Zhong,

Kang

et al. 2024

Journal of Medical Virology

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Systemic autoimmune diseases (SADs) are a growing spectrum of autoimmune disorders that commonly affect multiple organs. The role of Epstein–Barr virus (EBV) infection or reactivation as a trigger for the initiation and progression of SADs has been established, while the relationship between EBV envelope glycoproteins and SADs remains unclear. Here, we assessed the levels of IgG, IgA, and IgM against EBV glycoproteins (including gp350, gp42, gHgL, and gB) in serum samples obtained from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and found that RA and SLE patients exhibited a statistically significant increase in the levels of 8 and 11 glycoprotein antibodies, respectively, compared to healthy controls (p < 0.05). The LASSO model identified four factors as significant diagnostic markers for RA: gp350 IgG, gp350 IgA, gHgL IgM, and gp42 IgA; whereas for SLE it included gp350 IgG, gp350 IgA, gHgL IgA, and gp42 IgM. Combining these selected biomarkers yielded an area under the curve (AUC) of 0.749 for RA and 0.843 for SLE. We subsequently quantified the levels of autoantibodies associated with SADs in mouse sera following immunization with gp350. Remarkably, none of the tested autoantibody levels exhibited statistically significant alterations. Elevation of glycoprotein antibody concentration suggests that Epstein–Barr virus reactivation and replication occurred in SADs patients, potentially serving as a promising biomarker for diagnosing SADs. Moreover, the absence of cross‐reactivity between gp350 antibodies and SADs‐associated autoantigens indicates the safety profile of a vaccine based on gp350 antigen.

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“…Envelope glycoproteins have multiple important roles (reviewed in [ 29 ]) ranging from cellular entry [ 30 ] and viral assembly [ 31 ] to immune evasion [ 32 ]. EBV glycoproteins help dictate its preferential tropism for B cells, which has important implications in generating B-cell pathologies [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

EBV and Lymphomagenesis

Sausen

Basith

Muqeemuddin³

2023

Cancers

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The clinical significance of Epstein–Barr virus (EBV) cannot be understated. Not only does it infect approximately 90% of the world’s population, but it is also associated with numerous pathologies. Diseases linked to this virus include hematologic malignancies such as diffuse large B-cell lymphoma, Hodgkin lymphoma, Burkitt lymphoma, primary CNS lymphoma, and NK/T-cell lymphoma, epithelial malignancies such as nasopharyngeal carcinoma and gastric cancer, autoimmune diseases such as multiple sclerosis, Graves’ disease, and lupus. While treatment for these disease states is ever evolving, much work remains to more fully elucidate the relationship between EBV, its associated disease states, and their treatments. This paper begins with an overview of EBV latency and latency-associated proteins. It will then review EBV’s contributions to select hematologic malignancies with a focus on the contribution of latent proteins as well as their associated management.

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How EBV Infects: The Tropism and Underlying Molecular Mechanism for Viral Infection

Cited by 29 publications

References 149 publications

RNA-cleaving DNAzymes for accurate biosensing and gene therapy

RNA-cleaving DNAzymes for accurate biosensing and gene therapy

Evaluation of serum Epstein–Barr virus envelope glycoproteins antibodies and their association with systemic autoimmune diseases

EBV and Lymphomagenesis

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