How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report

Giebułtowicz, Joanna; Polańska-Płachta, Małgorzata; Wroczyński, Piotr; Zaborowski, P; Polański, Jerzy A.

doi:10.1186/1746-1596-7-17

Cited by 7 publications

(10 citation statements)

References 24 publications

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“…Echinococcus in liver produces similar symptoms seen in liver cancer patients like mass, abdominal pain and jaundice. Gal −3, soluble E and N cadherin can be used as marker for differentiation between the two [16]. The values of Gal-3, soluble E cadherin was not estimation in our case.…”

Section: Discussionmentioning

confidence: 54%

Primary cervical hydatid cyst: a rare occurrence

et al. 2012

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Hydatid disease, a parasitic infection is caused by Echinococcus granulosus. It has serious impact on health and economy especially in countries where it is endemic. It occurs frequently in liver and lung. The disease is chronic and cyst can localize in different organs. A hydatid cyst occurrence in the head and neck is extremely rare. To know the distribution of disease can help in its control and prevention. We report a case of primary cervical hydatid cyst in 20 year old female. A high index of suspicion is required to diagnose hydatid cyst in rare locations like this. Hydatid cyst should be considered in differential diagnosis of benign swellings of head and neck region, so that it can be managed during surgery to prevent acute anaphylaxis.Virtual slidesThe virtual slides’ for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4915595218376646

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Section: Discussionmentioning

confidence: 54%

Primary cervical hydatid cyst: a rare occurrence

et al. 2012

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“…Publication bias was assessed by Egger's test (15) and p < 0.1 was considered to imply a significant publication bias. from Europe (21,40,41,43,45,48), and two studies came from Oceania (23,24); five studies were published as the abstracts (27,28,35,37,42) and 28 studies were published as the full texts (16-26, 29-34, 36, 38-41, 43-48); and 29 studies were of high quality (16-26, 29, 30, 32-39, 41-48), but four studies were of low quality (27,28,31,40).…”

Section: Discussionmentioning

confidence: 99%

Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis

Liu

et al. 2021

Front. Med.

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Background: Galectins, a family of β-galactoside-binding proteins, are related to the development and progression of various human diseases such as cancer, heart failure, and chronic kidney disease. However, its role in liver diseases is unclear.Methods: The PubMed, Embase, and Cochrane Library databases were searched. Hazard ratios (HRs), odds ratios (ORs), and mean differences (MDs) with 95% CIs were pooled to evaluate the association of the galectins with the outcomes and risk of liver diseases by a random effects model.Results: Thirty three studies involving 43 cohorts and 4,168 patients with liver diseases were included. In the patients with hepatocellular carcinoma (HCC), high expression of galectin-1 and -3 in the tissues was significantly associated with worse overall survival (galectin-1: HR = 1.94, 95% CI = 1.61–2.34, p < 0.001; galectin-3: HR = 3.29, 95% CI = 1.62–6.68, p < 0.001) and positive vascular invasion (galectin-1: OR = 1.74, 95% CI = 1.18–2.58, p = 0.005; galectin-3: OR = 2.98, 95% CI = 1.58–5.60, p = 0.001); but, high expression of galectin-4 and −9 in the tissues was significantly associated with better overall survival (galectin-4: HR = 0.53, 95% CI = 0.36–0.79, p = 0.002; galectin-9: HR = 0.56, 95% CI = 0.44–0.71, p < 0.001) and negative vascular invasion (galectin-4: OR = 0.36, 95% CI = 0.19–0.72, p = 0.003; galectin-9: OR = 0.60, 95% CI = 0.37–0.97, p = 0.037). Serum galectin-3 level was significantly higher in HCC (MD = 3.06, 95% CI = 1.79–4.32, p < 0.001), liver failure (MD = 0.44, 95% CI = 0.23–0.66, p < 0.001), liver cirrhosis (MD = 1.83, 95% CI = 1.15–2.51, p < 0.001), and chronic active hepatitis B (MD = 18.95, 95% CI = 10.91–27.00, p < 0.001); serum galectin-9 level was significantly higher in HCC (MD = 3.74, 95% CI = 2.57–4.91, p < 0.001) and autoimmune hepatitis (MD = 8.80, 95% CI = 7.61–9.99, p < 0.001).Conclusion: High galectin-1 and -3 and low galectin-4 and -9 expression indicate worse outcomes of patients with HCC. Serum galectin-3 and -9 levels are positively associated with the risk of chronic liver diseases.

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“…In this scenario, the authors suggest sEcadherin as a potential differential marker between echinococcosis and hepatic cancer, which has elevated sE-cadherin levels. 88 These data are of importance because some cases of echinococcosis clinically mimic hepatic malignancy. 89 The adhesion molecule sCD44 did not change in serum from patients with bacterial infection compared to healthy controls.…”

Section: Hematological Malignanciesmentioning

confidence: 99%

Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

et al. 2018

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Some surface markers are used to discriminate certain leukemic subpopulations that retain a greater oncogenic potential than others, and, for this reason, they were termed as leukemic stem cells, similar to the concept of cancer stem cells in carcinoma. Among these surface markers are proteins involved in cell-cell adhesion or cell-matrix adhesion, and they may play a role in the relapse of leukemia, similar to metastasis in carcinomas. The most important are epithelial cadherin, neural cadherin, epithelial cell-adhesion molecule, and CD44, which can be cleaved and released, and their soluble forms were found increased in serum levels of cancer patients, being implicated, in some cases, with progression, metastases, and relapse. In this review, we highlighted the role of these four adhesion molecules in carcinomas and hematological malignancies, mainly leukemia, and discuss if the serum levels of soluble forms can be correlated with the surface protein status on the leukemic cells. Accession of the soluble forms looks attractive, but their use as markers in cancer must be studied in association with other parameters, as there are significant changes in levels in other pathological conditions besides cancer. Studies correlating the levels of the forms with the status of the membrane-bound proteins in leukemic (stem) cells and correlating those parameters with relapse in leukemia may afford important knowledge and applicability of those serum markers in clinical practice. For instance, the expression of the membrane-bound forms of these adhesion proteins may have promising clinical use in leukemia and other hematological malignancies.

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How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report

Cited by 7 publications

References 24 publications

Primary cervical hydatid cyst: a rare occurrence

Primary cervical hydatid cyst: a rare occurrence

Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis

Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

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