How electromagnetic fields can influence adult stem cells: positive and negative impacts

Maziarz, Aleksandra; Kocan, Beata; Bester, Mariusz; Budzik, Sylwia; Cholewa, M.; Ochiya, Takahiro; Banas, Agnieszka

doi:10.1186/s13287-016-0312-5

Cited by 112 publications

(100 citation statements)

References 47 publications

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“…The amplification of the signal to a biological response in past years has been thought to be driven solely by the chemical messengers and receptors, but now, there is evidence that the molecular mechanisms may not be the only factors involved in the biological communication. Chemical messengers are perhaps the particle components modulated by the governing energy fields which underlie the signal transduction [4,5]. Our results highlight the beneficial effects of the ELF-EMF on the immune reactions by the stimulation of the T lymphocytes proliferation and by the regulation of the cytokines and free radicals, biological processes that are necessary in the healing of wounds.…”

Section: Staphylococcus Aureusmentioning

confidence: 80%

Electromagnetic Field Therapy and Immune Mechanisms Which Are Involved in Anti-Inflammatory Response

Surcel¹,

Surcel²,

Toader³

et al. 2017

RAD Conference Proceedings

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Abstract. The aim of this study was to evaluate the mechanism by which EMF therapy can interfere with the modified immune and oxidative reactions by the experimental approach on the lab animals. In vivo and vitro experiment was carried out on 60 Wistar rats that were divided in 4 groups as following: 1. Control-group tested on the 10 th day; 2. LF-EMF-exposed group tested on the 10 th day; 3. Group that received intradermic Staphylococcus aureus culture (SA) and was tested on the 10 th day; 4. Group that received intradermic SA and was treated with LF-EMF and was tested after 10 days. The rats were exposed to 50 Hz, 1 mT. Splenic lymphocytes and alveolar macrophages for the cellular cultures were harvested. The following parameters were assessed: a) 3HTdR incorporation test; b) Macrophage inhibition factor (MIF) assay; c) IL-1 assay; d) TNF-assay; e) Chemiluminescence assay; f) Phagocytosis assay. The 3HTdR incorporation test, tests targeting the cytokine's activity and the phagocytosis test point out a partial reversibility of the values in the EMF-exposed groups that was treated with staphylococcus cultures. Our experiment reveals that the EMF interferes with the immune and oxidative systems, becomes chronic and plays a key role in the development of serious diseases. The EMF-therapy can be beneficial in reducing the inflammation by interfering with the inflammatory molecules and surface receptors.

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Section: Staphylococcus Aureusmentioning

confidence: 80%

Electromagnetic Field Therapy and Immune Mechanisms Which Are Involved in Anti-Inflammatory Response

Surcel¹,

Surcel²,

Toader³

et al. 2017

RAD Conference Proceedings

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show abstract

“…Numerous investigations have shown that ELF-EMFs can stimulate the division of stem cells [37][38][39][40][41]. It is well established that exposure to ELF-EMFs results in induction of electric fields and associated currents in tissues, an effect that has been used to promote tissue regeneration [1,42,43].…”

Section: Elf-emfs May Increase the Risk Of Childhood Leukemia By Prommentioning

confidence: 99%

“…This effect has been observed with relatively weak magnetic fields (µT and mT) [1,44]. Since the division of stem cells is crucial for tissue regeneration, it is not surprising that ELF-EMFs can stimulate the division of stem cells of a variety of tissues [37][38][39][40][41].…”

Section: Elf-emfs May Increase the Risk Of Childhood Leukemia By Prommentioning

confidence: 99%

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A Plausible Biological Mechanism by which Extremely Low-Frequency Electromagnetic Fields Increase the Risk of Childhood Leukemia

López‐Lázaro

2016

Preprint

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Abstract:Extremely low-frequency electromagnetic fields (ELF-EMFs) are non-ionizing radiations typically emitted by power lines, electrical wiring and electrical appliances. Epidemiological studies have repeatedly shown a positive association between ELF-EMFs and childhood leukemia. Exposures greater than 0.3-0.4 µT increase the risk by approximately 1.5-2 fold, and estimates indicate that up to 2% of childhood leukemia cases in Europe may be attributable to ELF-EMFs. However, it is considered unlikely that ELF-EMFs can cause cancer, because carcinogenesis requires the accumulation of DNA alterations and ELF-EMFs do not have enough energy to damage the DNA. Lack of biological plausibility is a barrier to accept the evidence of carcinogenicity in human studies and to take measures to protect pregnant women and children from ELF-EMFs. Recent evidence indicates that non-mutagenic agents can cause DNA alterations and increase the risk of cancer by promoting the accumulation of cell divisions in stem cells. Cell division generates DNA alterations (e.g., mutations arising during DNA replication), which occur even in the absence of DNA-damaging agents. Importantly, ELF-EMFs can trigger the division of stem cells; this effect is under development in the field of regenerative medicine. A possible mechanism by which ELF-EMFs induce the malignant transformation of hematopoietic stem cells is discussed.

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“…It is also known that HSCs migrate during embryonic development and early childhood; the migration of HSCs allows different sites to participate in hematopoiesis at different moments in life [184,185]. Importantly, numerous investigations have shown that ELF-EMFs can stimulate the division of stem cells and promote tissue regeneration [34,[186][187][188][189][190][191][192]. In addition, cell migration is regulated by physiological electric currents [123,[193][194][195], and ELF-EMFs are known to induce electric currents that can alter cell migration [34,88,191,192,[196][197][198].…”

Section: The Stem Cell Division Theory Of Cancer Provides a New Framementioning

confidence: 99%

The Stem Cell Division Theory of Cancer

López‐Lázaro

2017

Preprint

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All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and this cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the disease and has important implications for cancer prevention and therapy.

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How electromagnetic fields can influence adult stem cells: positive and negative impacts

Cited by 112 publications

References 47 publications

Electromagnetic Field Therapy and Immune Mechanisms Which Are Involved in Anti-Inflammatory Response

Electromagnetic Field Therapy and Immune Mechanisms Which Are Involved in Anti-Inflammatory Response

A Plausible Biological Mechanism by which Extremely Low-Frequency Electromagnetic Fields Increase the Risk of Childhood Leukemia

The Stem Cell Division Theory of Cancer

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