How Factors Involved in the Resolution of Crystal-Induced Inflammation Target IL-1β

Oliviero, Francesca; Scanu, Anna

doi:10.3389/fphar.2017.00164

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…In addition, miRNA 146a suppresses gouty inflammation via the downregulation of IL-1β, TNF, and NLRP3 levels by targeting TRAF6 and NF-kB signaling pathways [ 37 ]. Furthermore, exogenous substances, introduced with diet, can be involved in resolution of crystal-induced inflammation [ 38 ]. They can have immune, inflammatory, or regulatory properties.…”

Section: Resolution Of Gouty Inflammationmentioning

confidence: 99%

Autoinflammatory Features in Gouty Arthritis

Galozzi

Bindoli

Doria

et al. 2021

JCM

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In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation provoke crystal deposits in joints. However, since hyperuricemia alone is not sufficient to develop gout, molecular-genetic contributions are necessary to better clinically frame the disease. Herein, we review the autoinflammatory features of gout, from clinical challenges and differential diagnosis, to the autoinflammatory mechanisms, providing also emerging therapeutic options available for targeting the main inflammatory pathways involved in gout pathogenesis. This has important implication as treating the autoinflammatory aspects and not only the dysmetabolic side of gout may provide an effective and safer alternative for patients even in the prevention of possible gouty attacks.

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Section: Resolution Of Gouty Inflammationmentioning

confidence: 99%

Autoinflammatory Features in Gouty Arthritis

Galozzi

Bindoli

Doria

et al. 2021

JCM

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“…These diseases are caused by the deposition of, respectively, monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals in articular or periarticular tissues. These crystals provoke an acute, intense inflammatory reaction characterised by massive leucocyte recruitment and the local release of cytokines, chemokines, reactive oxygen species and proteolytic enzymes …”

Section: Polyphenols In Crystal‐induced Arthritismentioning

confidence: 99%

Anti‐inflammatory effects of polyphenols in arthritis

et al. 2017

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Polyphenols have been extensively investigated with regard to their antioxidant, anti-inflammatory, and immunomodulant properties in many inflammatory chronic conditions. The aim of this review is to summarise how these compounds can modulate the inflammatory pathways which characterise the most prevalent arthropathies including osteoarthritis, rheumatoid arthritis and crystal-induced arthritis. Among polyphenols, epigallocatechin gallate, carnosol, hydroxytyrosol, curcumin, resveratrol, kaempferol and genistein have been the most widely investigated in arthritis. The most important results of the studies outlined in this article show how polyphenolic compounds are able to inhibit the expression and the release of a number of pro-inflammatory mediators and proteolytic enzymes, the activity of different transcriptional factors and the production of reactive oxygen species in vitro. Studies on animal models of rheumatoid arthritis, osteoarthritis and gout show interesting results in terms of reduced tissue damage, restored cartilage homeostasis, and decreased levels of uric acid, respectively. Despite the multiple protective effects of polyphenols, there are no dietary recommendations for patients affected by rheumatic diseases. Future studies, including intervention trials, should be conducted to determine the relevance of polyphenols consumption or supplementation in arthritis. © 2017 Society of Chemical Industry.

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“…Further, these drugs focus on diminishing the symptoms rather than curing the patient. Of note, novel molecules targeting the aggregation of neutrophil extracellular traps are in development (17). In the long term, though with limited expected benefits, lifestyle modifications are also recommended (15).…”

Section: Introductionmentioning

confidence: 99%

Where Epigenetics Meets Food Intake: Their Interaction in the Development/Severity of Gout and Therapeutic Perspectives

Georgel

2021

Front. Immunol.

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Gout is the most frequent form of inflammatory arthritis in the world. Its prevalence is particularly elevated in specific geographical areas such as in the Oceania/Pacific region and is rising in the US, Europe, and Asia. Gout is a severe and painful disease, in which co-morbidities are responsible for a significant reduction in life expectancy. However, gout patients remain ostracized because the disease is still considered “self-inflicted”, as a result of unhealthy lifestyle and excessive food and alcohol intake. While the etiology of gout flares is clearly associated with the presence of monosodium urate (MSU) crystal deposits, several major questions remain unanswered, such as the relationships between diet, hyperuricemia and gout flares or the mechanisms by which urate induces inflammation. Recent advances have identified gene variants associated with gout incidence. Nevertheless, genetic origins of gout combined to diet-related possible uric acid overproduction account for the symptoms in only a minor portion of patients. Hence, additional factors must be at play. Here, we review the impact of epigenetic mechanisms in which nutrients (such as ω-3 polyunsaturated fatty acids) and/or dietary-derived metabolites (like urate) trigger anti/pro-inflammatory responses that may participate in gout pathogenesis and severity. We propose that simple dietary regimens may be beneficial to complement therapeutic management or contribute to the prevention of flares in gout patients.

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How Factors Involved in the Resolution of Crystal-Induced Inflammation Target IL-1β

Cited by 9 publications

References 41 publications

Autoinflammatory Features in Gouty Arthritis

Autoinflammatory Features in Gouty Arthritis

Anti‐inflammatory effects of polyphenols in arthritis

Where Epigenetics Meets Food Intake: Their Interaction in the Development/Severity of Gout and Therapeutic Perspectives

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