How gallic acid regulates molecular signaling: role in cancer drug resistance

Hassani, Samira; Ghanbari, Fahimeh; Lotfi, Marzieh; Alam, Waqas; Aschner, Michael; Popović-Djordjević, Jelena; Shahcheraghi, Seyed Hossein; Khan, Haroon

doi:10.1007/s12032-023-02178-4

Cited by 6 publications

(2 citation statements)

References 147 publications

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“…Additionally, gallic acid inhibits the processes of carcinogenesis through activating ATM kinase signaling pathways. Furthermore, gallic acid is found to show synergism with other existing chemotherapeutic drugs [18][19][20][21][22].…”

Section: Phenolic Acidsmentioning

confidence: 99%

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Požgajová,

Klongová,

Kovár

et al. 2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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Stress caused by challenging environmental conditions is often associated with the rapid production of reactive oxygen species (ROS) that dramatically alter cellular redox homeostasis. ROS generation is tightly connected with its utilization, as impaired equilibrium of these processes results in oxidative stress having profound consequences for cell physiology. The balanced action of both antioxidant enzymes and non-enzymatic antioxidants counterbalances the harmful effects of ROS. Despite the functional antioxidant system of the cell, excessive ROS leads to disruption of vital cellular processes which is associated with the development of various lifestyle diseases, mainly cardiovascular diseases, and cancer. Enhanced consumption of foodstuffs with high and balanced antioxidant bioactive compounds is linked with the positive effects of beneficial antioxidants impacting cellular protection resulting in health promotion. In this chapter, we present an outline of how bioactive compounds determine their health-promoting properties.

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Section: Phenolic Acidsmentioning

confidence: 99%

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Požgajová,

Klongová,

Kovár

et al. 2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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“…The phytcomplex of Epilobium species comprises a variety of bioactive constituents acknowledged for their anti-inflammatory and antitumor properties, including compounds like myricetin [ 40 , 41 , 42 ], hyperoside [ 43 , 44 , 45 ], quercitrin [ 46 , 47 ], kaempferol [ 48 , 49 ], gallic acid [ 50 , 51 , 52 , 53 ], catechin [ 54 , 55 ], and beta-sitosterol [ 56 , 57 ], among others. The synergistic effects of these compounds when present in total extracts play a significant role in enhancing biological activity.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Epilobium hirsutum L. Optimized Extract’s Anti-Inflammatory and Antitumor Potential

Vlase,

Toiu,

Gligor

et al. 2024

Plants

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Epilobium hirsutum L., commonly known as hairy willowherb, is a perennial herbaceous plant native to Europe and Asia. In Romania, the Epilobium genus includes 17 species that are used in folk medicine for various purposes. This study aimed to investigate the anti-inflammatory and antitumor potential of the optimized extract of Epilobium hirsutum (EH) in animal models. The first study investigated the anti-inflammatory properties of EH optimized extract and the model used was carrageenan-induced paw inflammation. Wistar rats were divided into three groups: negative control, positive control treated with indomethacin, and a group treated with the extract. Oxidative stress markers, cytokine levels, and protein expressions were assessed. The extract demonstrated anti-inflammatory properties comparable to those of the control group. In the second study, the antitumor effects of the extract were assessed using the tumor model of Ehrlich ascites carcinoma. Swiss albino mice with Ehrlich ascites were divided into four groups: negative, positive treated with cyclophosphamide (Cph), Group 3 treated with Cph and EH optimized extract, and Group 4 treated with extract alone. Samples from the ascites fluid, liver, and heart were analyzed to evaluate oxidative stress, inflammation, and cancer markers. The extract showed a reduction in tumor-associated inflammation and oxidative stress. Overall, the EH optimized extract exhibited promising anti-inflammatory and antitumor effects in the animal models studied. These findings suggest its potential as a natural adjuvant therapeutic agent for addressing inflammation and oxidative stress induced by different pathologies.

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Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics

Ye,

Bao,

Chen

et al. 2024

Coordination Chemistry Reviews

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How gallic acid regulates molecular signaling: role in cancer drug resistance

Cited by 6 publications

References 147 publications

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Investigation of Epilobium hirsutum L. Optimized Extract’s Anti-Inflammatory and Antitumor Potential

Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics

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