How ginseng regulates autophagy: Insights from multistep process

Ren, Han-Gui; Dai, Rongchen; Chen, Yin-Chen; Xi, Zhichao; Xu, Hong‐Xi

doi:10.1016/j.biopha.2022.114139

Cited by 7 publications

(3 citation statements)

References 122 publications

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“…However, their other study based on the same cohort showed that although regular ginseng use was mostly not associated with the risk of any site-specific cancer, it may be associated with the risk of liver and thyroid cancers [ 33 ]. Many reviews have also summarized the positive effects of ginseng in the treatment of Alzheimer’s disease [ 9 ], stroke [ 34 ], sarcopenia [ 35 ], non-alcoholic fatty liver disease [ 36 ], and tumors [ 37 ], which might be related to the involvement of ginseng in immunomodulatory properties [ 38 , 39 ], anti-inflammatory [ 39 ], the regulation of signaling pathways [ 9 ], and the regulation of autophagy [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, Renshen (Panax ginseng), Gouqizi (Lycium barbarum), and Danggui (Angelica sinensis) are such Chinese herbal medicines. There are many studies on them to explore their health effects and mechanisms [ 9 , 10 , 11 , 12 , 13 ]. However, few of these studies focused on populations, especially those conducted in long-term follow-up cohorts.…”

Section: Introductionmentioning

confidence: 99%

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Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Tao,

Liao,

Zheng

et al. 2023

Nutrients

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The aim of this study was to explore whether drinking herbal tea and tea would positively benefit activities of daily living (ADL) in the elderly. We used data from the Chinese longitudinal healthy longevity survey (CLHLS) to explore the association. Drinking herbal tea and drinking tea were divided into three groups using latent class analysis (LCA): frequently, occasionally, and rarely. ADL disability was measured by the ADL score. Multivariate COX proportional hazards models with competing risks were used to explore the impact of drinking herbal tea and tea on ADL disability, statistically adjusted for a range of potential confounders. A total of 7441 participants (mean age 81.8 years) were included in this study. The proportions of frequently and occasionally drinking herbal tea were 12.0% and 25.7%, respectively. Additionally, 29.6% and 28.2% of participants reported drinking tea, respectively. Multivariate COX regression showed that compared with rarely drinking, frequently drinking herbal tea could effectively reduce the incidence of ADL disability (HR = 0.85, 95% CI = 0.77–0.93, p = 0.005), whereas tea drinking had a relatively weaker effect (HR = 0.92, 95% CI = 0.83–0.99, p = 0.040). Subgroup analysis found that frequently drinking herbal tea was more protective for males under 80 years old (HR = 0.74 and 0.79, respectively), while frequently drinking tea was somewhat protective for women (HR = 0.92). The results indicate that drinking herbal tea and tea may be associated with a lower incidence of ADL disability. However, the risks associated with using Chinese herb plants still deserve attention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Tao,

Liao,

Zheng

et al. 2023

Nutrients

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“…Ginseng contains various active components, among which over 100 ginsenosides are the material basis for its various pharmacological activities [4]. Various ginsenosides can regulate autophagy in cancer cells through various pathways [5]. Ginseng and its preparations (Shenmai injection, for examples) are often prescribed as botanical dietary supplements or medicinal product for cancer patients in China, which can regulate the immune function of patients and has a certain auxiliary anticancer effect [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Ginsenosides Rh2 and Rg3 exert their anti-cancer effects on non-small cell lung cancer by regulating cell autophagy and choline-phosphatidylcholine metabolism

Chen

Qiu

Wang

et al. 2023

Preprint

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Background: Ginseng (Panax ginseng C. A. Meyer) herb itself and its derived preparations (e.g. Shenmai injection) are often prescribed for cancer patients as Traditional Chinese Medicines clinically in China. Ginsenosides Rh2 and Rg3 are two of main active components of ginseng. They have significant cytotoxic effect against non-small cell lung cancer (NSCLC), but the mechanisms are not very clear, especially lack of research on the combination of cell autophagy and metabolism. This study explores the mechanism of ginsenosides Rh2 and Rg3 against NSCLC from these two aspects. Methods: In this study, we investigated the regulatory effects of ginsenosides Rh2 and Rg3 on cellular autophagy and metabolism in non-small cell lung cancer cell lines. Their regulations of cellular autophagy were detected by immunofluorescence, MDC staining, and transmission electron microscopy, while their regulations of cellular metabolism were detected by cellular metabolomics. Results: Our results showed that ginsenosides Rh2 and Rg3 can significantly induce cell autophagy, and can lead to autophagic cell death through endoplasmic reticulum stress-autophagy axis, similar to ginseng total ginsenosides extract (TGS). They also significantly regulate the cell metabolome at the same time. The regulatory effect of ginsenosides Rh2 and Rg3 on the metabolism of choline-phosphatidylcholinemay be the cellular metabolic mechanism of their cytotoxicity. Conclusion: Our findings suggested that ginsenosides Rh2 and Rg3 could induce autophagic cell death and regulate choline-phosphatidylcholine metabolism in NSCLC cells. This study has a new understanding of the antitumor mechanism of ginsenosides Rh2 and Rg3, and suggests a new direction of studying the pharmacological mechanism of natural active components.

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Regulation of Autophagy Signaling Pathways by Ginseng Saponins: A Review

Zhuang,

Li,

et al. 2024

Chemistry & Biodiversity

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Ginseng saponins ( ginsenosides), bioactive compounds derived from ginseng, are widely used natural products with potent therapeutic properties in the management of various ailments, particularly tumors, cardiovascular and cerebrovascular diseases, and immune system disorders. Autophagy, a highly regulated and multistep process involving the breakdown of impaired organelles and macromolecules by autophagolysosomes and autophagy‐related genes (ATGs), has gained increasing attention as a potential target for ginsenoside‐mediated disease treatment. This review aims to provide a comprehensive overview of recent research advances in the understanding of autophagy‐related signaling pathways and the role of ginsenoside‐mediated autophagy regulation. By delving into the intricate autophagy signaling pathways underpinning the pharmacological properties of ginsenosides, we highlight their therapeutic potential in addressing various conditions. Our findings serve as a comprehensive reference for further investigation into the medicinal properties of ginseng or ginseng‐related products.

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How ginseng regulates autophagy: Insights from multistep process

Cited by 7 publications

References 122 publications

Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Ginsenosides Rh2 and Rg3 exert their anti-cancer effects on non-small cell lung cancer by regulating cell autophagy and choline-phosphatidylcholine metabolism

Regulation of Autophagy Signaling Pathways by Ginseng Saponins: A Review

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