How graphene is expected to impact neurotherapeutics in the near future

Mattei, Tobias A.

doi:10.1586/14737175.2014.925804

Cited by 12 publications

(16 citation statements)

References 20 publications

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“…Scaffolds that can be used for SCI were illustrated in depth by Zhang and colleagues and include: Biodegradable synthetic polymer scaffolds (PCL, PLA, PLGA, PEG), non-biodegradable synthetic polymer scaffolds (PHEMA, PHPMA, PAN/PVC, conductive polymers), and natural polymer scaffolds (collagen, chitosan, alginate, fibrin) [ 256 ]. An interesting and promising technology is represented by graphene oxide (GO) 3-D nano-structured scaffolds, able to stimulate neuronal differentiation thanks to unique electro-physico-chemical properties [ 257 , 258 , 259 , 260 ]. To this end, a key player in providing structural support could also be the physiological tissue, such as adipose tissue, which has proved promising in the treatment of the disease [ 261 , 262 ].…”

Section: The Role Of Scaffolds In Developing Regenerative Therapiementioning

confidence: 99%

Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases

Rey

Barzaghini

Nardini

et al. 2020

Cells

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In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more and more relevance proving the great potential of the fabrication of precision 3-D scaffolds. In this review, recent advances in additive manufacturing techniques are presented and discussed, with an overview on stimulus-triggered approaches, such as 3-D Printing and laser-based techniques, and deposition-based approaches. Innovative 3-D bioprinting techniques, which allow the production of cell/molecule-laden scaffolds, are becoming a promising frontier in disease modelling and therapy. In this context, the specific biomaterial, stiffness, precise geometrical patterns, and structural properties are to be considered of great relevance for their subsequent translational applications. Moreover, this work reports numerous recent advances in neural diseases modelling and specifically focuses on pre-clinical and clinical translation for scaffolding technology in multiple neurodegenerative diseases.

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Section: The Role Of Scaffolds In Developing Regenerative Therapiementioning

confidence: 99%

Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases

Rey

Barzaghini

Nardini

et al. 2020

Cells

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“…Studies have shown graphene to have great potential as a bioscaffold at the site of the lesion in chronic SCI allowing for neuronal regeneration [ 4 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. GO nanocomposite is considered to be a favorable material for use in treatment because of its unique electro-physico-chemical properties and it is conductivity.…”

Section: Selected Biomaterials That Hold Promise For Future Clinicmentioning

confidence: 99%

Translational Regenerative Therapies for Chronic Spinal Cord Injury

Dalamagkas

Tsintou

Seifalian

et al. 2018

IJMS

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Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time to start interventions, the chronic phase is definitely the most stable target in order to determine whether a therapy can effectively restore neurological function. The advancements of nanoscience and stem cell technology, combined with the powerful, novel neuroimaging modalities that have arisen can now accelerate the path of promising novel therapeutic strategies from bench to bedside. Several types of stem cells have reached up to clinical trials phase II, including adult neural stem cells, human spinal cord stem cells, olfactory ensheathing cells, autologous Schwann cells, umbilical cord blood-derived mononuclear cells, adult mesenchymal cells, and autologous bone-marrow-derived stem cells. There also have been combinations of different molecular therapies; these have been either alone or combined with supportive scaffolds with nanostructures to facilitate favorable cell–material interactions. The results already show promise but it will take some coordinated actions in order to develop a proper step-by-step approach to solve impactful problems with neural repair.

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“…However, they have limited durability and low conversion efficiency due to the large energy gap. 56,59,[68][69][70][71][72][73][74] Dye-sensitized solar cell They are formed by organic and inorganic materials. The cost of manufacturing compared with other technologies is reduced due to the use of impure raw materials and simple cell processing.…”

Section: Technology Descriptionmentioning

confidence: 99%

Prospecting technologies for photovoltaic solar energy: Overview of its technical‐commercial viability

et al. 2019

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There are many technologies that may emerge and eventually disappear over the years. This fact makes the monitoring of technological trends as well as the anticipation of the direction of technological change paramount. This article aims to carry out the prospection of technologies, focusing on its technicalcommercial viability, for solar photovoltaic energy. The research method had a qualititative-quantitative approach with application of the Delphi technique. In the conduction of the Delphi technique, seven steps were followed, ranging from the selection of the specialists to the considerations of their opinions regarding the future of nine photovoltaic technologies. The results of the research indicate that in 2020, the cells monocrystalline, multicrystalline, and amorphous silicon; cadmium telluride; indium/copper selenide, indium, and gallium diselenide; and multicompound III-V cells will have technical and commercial viability and that dye-sensitized silicon nanowire and carbon nanostructure-based cells will not be viable. For the year 2025, monocrystalline and multicrystalline silicon cells and those of multicompounds III-V will still be technically and commercially viable. Silicon nanowire; amorphous silicon; cadmium telluride; indium/copper, selenium, and gallium diselenide dyesensitized cells; and organic photovoltaic cells, including those based on carbon nanostructure, may be viable. This study is important, because the technological prospecting of the photovoltaic cells determines the possible trajectories of these cells, in a way that helps the companies of the sector to anticipate the strategic scenarios, thus facilitating the decision making process.

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How graphene is expected to impact neurotherapeutics in the near future

Cited by 12 publications

References 20 publications

Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases

Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases

Translational Regenerative Therapies for Chronic Spinal Cord Injury

Prospecting technologies for photovoltaic solar energy: Overview of its technical‐commercial viability

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