How harmful can herbal remedies be? a case of severe acute tubulointerstitial nephritis

Beniwal, Pankaj; Gaur, Navendu; Singh, Sachidanand; Raveendran, N; Malhotra, Vinay

doi:10.4103/ijn.ijn_313_16

Cited by 5 publications

(5 citation statements)

References 10 publications

(10 reference statements)

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“…A case of acute interstitial nephritis was reported in a 60-years male with T2DM and hypertension that used hyponidd, an ayurvedic drug containing M. charantia . The patient took one hyponidd tablet daily for 1 week before the onset of his symptoms: edema and a decrease in urine, which progressed to complete anuria in 2–3 days (Beniwal et al, 2017). The toxicity for kidney was already reported in mice treated with MC 4 g/kg for more than a week (Mardani et al, 2014).…”

Section: Safety Of Momordica Charantiamentioning

confidence: 99%

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

2019

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Momordica charantia , commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its pharmacological activities, and nutritional properties. Due to the presence of many bioactive compounds, some of which possess potent biological actions, this plant is used in folk medicine all over the world for the treatment of different pathologies, mainly diabetes, but also cancer, and other inflammation-associated diseases. It is widely demonstrated that M. charantia extracts contribute in lowering glycaemia in patients affected by type 2 diabetes. However, the majority of existing studies on M. charantia bioactive compounds were performed only on cell lines and in animal models. Therefore, because the real impact of bitter melon on human health has not been thoroughly demonstrated, systematic clinical studies are needed to establish its efficacy and safety in patients. Besides, both in vitro and in vivo studies have demonstrated that bitter melon may also elicit toxic or adverse effects under different conditions. The aim of this review is to provide an overview of anti-inflammatory and anti-neoplastic properties of bitter melon, discussing its pharmacological activity as well as the potential adverse effects. Even if a lot of literature is available about bitter melon as antidiabetic drug, few papers discuss the anti-inflammatory and anti-cancer properties of this plant.

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Section: Safety Of Momordica Charantiamentioning

confidence: 99%

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

2019

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“…AIN induced by drugs has been observed in 6.5–27% of patients when a renal biopsy was performed due to unexplained AKI [ 8 – 10 ]. AIN has been reported after ingesting herbal and folk medicines [ 11 – 13 ]. A. japonica has been ingested in South Korea for a long time to control arthralgia.…”

Section: Discussionmentioning

confidence: 99%

Acute interstitial nephritis associated with ingestion of Achyranthes japonica extract: a case report

et al. 2021

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Background The Japanese chaff flower, Achyranthes japonica, is used as complementary medicine to control degenerative arthritis. Although commonly used in South Korea, there has been no report of side effects. We report the first case of acute interstitial nephritis (AIN) that occurred in a woman who ingested A. japonica extract for 4 months. Case presentation A 56-year-old Korean woman was admitted for deterioration of renal function. She had general weakness and nausea for 1 month. Her initial blood urea nitrogen and serum creatinine levels were 26.3 mg/dL and 3.2 mg/dL, respectively. She acknowledged ingesting A. japonica extract for the past 4 months. Renal histology demonstrated AIN represented by immune cell infiltration into the interstitium, tubulitis, and tubular atrophy, but the glomeruli were intact. A. japonica was discontinued immediately and conservative management was started. Renal function was nearly restored to the baseline level without medication after 13 months. Conclusion This is a rare case report of AIN associated with a pure A. japonica extract. In the case of unknown etiology of AIN, physicians should ask about the use of herbal medicines, nutraceuticals, and traditional folk medicines including A. japonica.

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“…Only 1 case of AIN associated with M charantia has been reported in a patient with T2DM and hypertension in the English literature [ 12 ] That patient had taken 1 hyponidd tablet per day for 7 days before the onset of symptoms. Hyponidd usually contains 10 active ingredients, including M charantia .…”

Section: Discussionmentioning

confidence: 99%

“…Medicine ® OPEN literature [12] We report an additional case of AIN occurring after ingestion of pure M charantia extract.…”

Section: Clinical Case Reportmentioning

confidence: 98%

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Acute interstitial nephritis associated with ingesting a Momordica charantia extract

et al. 2021

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Rationale: Momordica charantia is often used to treat type 2 diabetes mellitus in Korea. Drug-induced acute interstitial nephritis (AIN) accounts for 60% to 70% of AIN cases. However, only 1 case of AIN associated with ingesting M charantia has been reported in the English literature. We report an extremely rare case of AIN that occurred after a patient ingested a pure M charantia extract over 7 months. Patient concerns: A 60-year-old Korean woman was admitted to our hospital for a renal biopsy. Her renal function had decreased gradually over the last 9 months without symptoms or signs. Diagnosis: Her blood urea nitrogen and serum creatinine levels were 29.7 mg/dL (range: 8.0–20.0 mg/dL) and 1.45 mg/dL (range: 0.51–0.95 mg/dL) on admission. Renal histology indicated AIN; there was immune cell infiltration into the interstitium, tubulitis, and epithelial casts, although the glomeruli were largely intact. Interventions: M charantia was discontinued and prednisolone was prescribed. Outcomes: The value of serum creatinine has almost been restored to the baseline level after 3 months. Conclusion s: This is the first case report of AIN associated with the ingestion of a pure M charantia extract. Recognition of the possible adverse effects of these agents by physicians is very important for early diagnosis and appropriate management.

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How harmful can herbal remedies be? a case of severe acute tubulointerstitial nephritis

Cited by 5 publications

References 10 publications

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

Acute interstitial nephritis associated with ingestion of Achyranthes japonica extract: a case report

Acute interstitial nephritis associated with ingesting a Momordica charantia extract

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