How HIV Treatment Could Result in Effective Prevention

Venkatesh, Kartik K.; Lurie, Mark N.; Mayer, Kenneth H.

doi:10.2217/fvl.10.38

Cited by 7 publications

(5 citation statements)

References 97 publications

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“…There are multiple ways in which antiretrovirals could be possibly used as means of primary and secondary HIV prevention, including pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) [24,113,114], as well as by expanding treatment access to decrease the onward sexual transmission from infected individuals [115][116][117].…”

Section: Optimal Utilization Of a Limited Resourcementioning

confidence: 99%

Is expanded HIV treatment preventing new infections? Impact of antiretroviral therapy on sexual risk behaviors in the developing world

Venkatesh

Flanigan

Mayer

2011

Aids

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There have been dramatic increases in access to antiretroviral therapy (ART) across the developing world, and growing public health attention has focused on the possibility of utilizing ART as a means of slowing the global HIV epidemic. The preventive impact of ART will likely depend on decreasing levels of sexual risk behaviors following treatment initiation. The current review study examines the impact of wider access to ART on sexual risk behaviors among HIV-infected individuals in the developing world. The observational studies to date demonstrate that ART is associated with a significant reduction in unprotected sex following treatment initiation. Although data on the impact of ART on possible risk compensation are rapidly expanding across the developing world, more evidence is still needed before we can safely conclude expanded treatment will result in durable decreases in sexual risk behaviors.

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Section: Optimal Utilization Of a Limited Resourcementioning

confidence: 99%

Is expanded HIV treatment preventing new infections? Impact of antiretroviral therapy on sexual risk behaviors in the developing world

Venkatesh

Flanigan

Mayer

2011

Aids

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“…ART use results in substantial reductions in HIV-related morbidity and mortality [7, 8]. However, for ART to be effective, sustained viral suppression must be achieved through near-perfect pill adherence [9–11].…”

Section: Introductionmentioning

confidence: 99%

Antiretroviral Treatment Adherence: Knowledge and Experiences among Adolescents and Young Adults in Soweto, South Africa

Hornschuh

Dietrich

Tshabalala

et al. 2017

AIDS Research and Treatment

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Human immunodeficiency virus (HIV) management of adolescents and young adults (AYAs) is particularly pertinent to sub-Saharan Africa, where the pediatric HIV burden is marked. Antiretroviral treatment (ART) adherence is a major challenge for AYAs. This qualitative study explored knowledge and experiences of adherence amongst AYAs attending treatment at the Perinatal HIV Research Unit (PHRU), Soweto, South Africa. Four focus group discussions (FGDs) and eight in-depth interviews (IDIs) were conducted with HIV-infected 15–25-year-old ART recipients. Transcripts were coded thematically. Participants (n = 26) were aged median 18.5 years, 59.1% female and 69.2% virally suppressed <400 cp/ml. Three main themes emerged during FGDs and IDIs: (i) correct knowledge about how to be adherent, benefits, and nonadherence consequences, (ii) social, personal, and medication-related barriers to adherence, and (iii) reminder, concealment, and motivational strategies to optimize adherence. Interventions to improve AYA adherence could focus on practical strategies, including status disclosure and medication concealment.

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“…The treatment as prevention (TasP) strategy has gained importance and is seen as a win–win strategy not only due to individual health but also public health benefits [ 101 ]. Studies in this category not only support the potential of TasP to reduce the number of new HIV infections but also the economic benefits, despite its high costs.…”

Section: Methodsmentioning

confidence: 99%

The Cost-Effectiveness of HIV/STI Prevention in High-Income Countries with Concentrated Epidemic Settings: A Scoping Review

Brunner

Kübler

2022

AIDS Behav

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The purpose of this scoping review is to establish the state of the art on economic evaluations in the field of HIV/STI prevention in high-income countries with concentrated epidemic settings and to assess what we know about the cost-effectiveness of different measures. We reviewed economic evaluations of HIV/STI prevention measures published in the Web of Science and Cost-Effectiveness Registry databases. We included a total of 157 studies focusing on structural, behavioural, and biomedical interventions, covering a variety of contexts, target populations and approaches. The majority of studies are based on mathematical modelling and demonstrate that the preventive measures under scrutiny are cost-effective. Interventions targeted at high-risk populations yield the most favourable results. The generalisability and transferability of the study results are limited due to the heterogeneity of the populations, settings and methods involved. Furthermore, the results depend heavily on modelling assumptions. Since evidence is unequally distributed, we discuss implications for future research.

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How HIV Treatment Could Result in Effective Prevention

Cited by 7 publications

References 97 publications

Is expanded HIV treatment preventing new infections? Impact of antiretroviral therapy on sexual risk behaviors in the developing world

Is expanded HIV treatment preventing new infections? Impact of antiretroviral therapy on sexual risk behaviors in the developing world

Antiretroviral Treatment Adherence: Knowledge and Experiences among Adolescents and Young Adults in Soweto, South Africa

The Cost-Effectiveness of HIV/STI Prevention in High-Income Countries with Concentrated Epidemic Settings: A Scoping Review

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