Previous articles have mostly evaluated only radiological or clinical improvement to assess decompression. But there has been no detailed study in the literature evaluating both quality of life and functional and radiological improvement. In this study, we aimed to investigate the effectiveness of microsurgical unilateral laminotomy to perform bilateral decompression for degenerative lomber spinal stenosis. Materials and methods: We assessed 116 segments in 80 patients retrospectively. We evaluated clinical, functional and radiological improvement. For clinical evaluation Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Medical Outcomes Study 36-Item Short-Form Health Survey (SF36) were used. For radiological evalution, we assessed the changes of anterior and posterior disc height, lateral resses heigt, anteior-posterior diameter of spinal canal, spinal canal cross sectional area, segmental lordotic angle on preoperative and postoperative radiographic images. For functional evalution, walking performance was also evaluated by 15 Minutes Self Paced Walking Test. Results: The mean age of the patients was 58.6±11.3 years. Forty-two of them were females (52.5%), and thirtyeight were males (47.5%). Clinical outcomes, measured by VAS, ODI and SF36 were improved significantly. Walking performance, dural sac cross sectional area and other radiographic measurments were also improved significantly. Eight patients were reoperated due to the spinal instability, and 4 patients due to the dura repair. Only two wound infections developed. Conclusion: Microsurgical unilateral laminotomy for bilateral decompression for degenerative spinal stenosis achieves adequate decompression and satisfactory clinical outcomes with minimal tissue damage and less complications.