How I Do It

Sharma, Amita; Moore, William; Lanuti, Michael; Shepard, Jo-Anne O.

doi:10.1097/rti.0b013e3182171b75

Cited by 40 publications

(8 citation statements)

References 70 publications

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“…Cryoablation induces tissue damage mainly through two separate freezing-related events: a direct toxic effect on the cells and an indirect effect via actions on the tumor vasculature, with the end result being a coagulative necrosis [ 11 ]. The direct effect involves intra- and extracellular ice formation at temperatures below 0 °C and enzymatic and cell membrane dysfunction, resulting in osmosis of water out of the cells and cellular dehydration.…”

Section: Discussionmentioning

confidence: 99%

Cryoablation of cardiophrenic angle lymph node metastases: a case report

Luo

Long

et al. 2017

J Med Case Reports

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BackgroundCardiophrenic angle lymph node metastases are relatively rare. Surgical resection is the main treatment for cardiophrenic angle lymph node metastasis, but it is not always possible.Case presentationHere, we report our initial experience with cryoablation of a cardiophrenic angle lymph node metastasis from liver cancer. As the cardiophrenic angle lymph node metastasis was located close to the heart, about 200 mL of 0.9% saline was injected into the pericardium to separate the heart from the target area. The cardiophrenic angle lymph node metastasis was successfully ablated, without any complications.ConclusionsCryoablation may be a suitable alternative treatment for cardiophrenic angle lymph node metastasis.

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Section: Discussionmentioning

confidence: 99%

Cryoablation of cardiophrenic angle lymph node metastases: a case report

Luo

Long

et al. 2017

J Med Case Reports

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“…The final result is a coagulative necrosis. [ 7 ] The direct effect involves enzymatic and cell membrane dysfunction caused by intra- and extra-cellular ice formation at temperatures below 0°C,[ 7 ] resulting in osmosis of water out of the cells and cellular dehydration. During the thawing cycle, water returns to the intracellular space and causes cellular lysis.…”

Section: Discussionmentioning

confidence: 99%

“…The indirect effect results in occlusion of small blood vessels because of the extreme cold. [ 7 ] The present study involved three cases of lung malignancies (one metastasis from leiomyosarcoma, one NSCLC and one metastasis from pancreatic carcinoma) that recurred close to surgical clips at a site of previous surgical treatment. In each case, the decision to perform cryoablation was influenced mainly by the presence of the clips close to the lesion, and the need to avoid potential RFA-related thermal damage due to overheating of the clips, resulting in unpredictable necrosis.…”

Section: Discussionmentioning

confidence: 99%

Cryoablation of lung malignancies recurring close to surgical clips following surgery: Report of three cases

Grasso

Luppi

Cazzato

et al. 2015

Indian Journal of Radiology and Imaging

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Background:Minimally ablative therapies are now available for the treatment of lung malignancies. However, selection of the appropriate technique is not always easy and requires accurate preoperative planning.Aims:To describe the treatment of lung tumors with cryoablation.Settings and Design:We report three cases of lung malignancies that recurred close to surgical clips after surgical treatment, successfully treated by cryoablation.Materials and Methods:An initial freezing cycle was performed for 10 min, followed by a 5-min thawing cycle, and an additional 10-min freezing cycle. A final 5-min thaw was necessary to remove the needle from the iceball formed during the freezing cycle.Results:The procedures were completed successfully with no signs of surgical-clip misplacement, and excellent ablation of the lesions.Conclusion:Cryoablation is a relatively new procedure that potentially permits the local treatment of lung tumors with minimal loss of lung parenchyma.

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“…Electrodes conduct an alternating current, which is converted to heat with target temperatures between 60 and 100°C resulting in coagulative necrosis. 122 It is vital that the tumour lies entirely within ablated zone hence a "safety zone" of 10 mm surrounding the tumour is recommended. RFA is therefore most effective in peripheral tumours ,3 cm, which are not in contact with pleura, large vessels or mediastinal structures.…”

Section: Radiofrequency Ablationmentioning

confidence: 99%

“…126 After 3 months, the lesion usually becomes smaller and may become wedge shaped or linear owing to fibrosis (Figure 7). 122 Increase in size after 3 months, eccentric growth or eccentric enhancement on CT should be viewed as suspicious for local recurrence. 126 PET-CT appearances after ablation can vary with diffuse, focal, heterogeneous, rim or rim plus focal uptake.…”

Section: Radiofrequency Ablationmentioning

confidence: 99%

Lung cancer: from screening to post-radical treatment

Panditaratne¹,

Slater²,

Robertson³

2014

Imaging

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Initial data from North America shows reduction in lung cancer-related mortality following the use of CT screening. • Staging with TNM 7 has replaced TNM 6 based on evidence-based outcomes reflecting advances in diagnosis and treatment. • CT remains the workhorse for initial diagnostic imaging in lung cancer; however, the uses for positron emission tomography (PET)-CT are ever increasing with greater sensitivity and specificity for staging. • Endoscopic ultrasound-guided nodal sampling via the airways and oesophagus is replacing the need for surgical mediastinal sampling and preventing unnecessary thoracotomies. • Ultrasound-guided sampling of neck nodes should be considered in those patients with mediastinal adenopathy. • Knowledge of potential surgical procedures and their imaging features is vital for reporting radiologists in order to recognize the potential complications. • Stereotactic body radiotherapy-associated changes include ground-glass opacity, consolidation and fibrosis. PET-CT is a helpful adjunct in the follow-up of these patients. • Radiofrequency ablation, cryoablation and microwave ablation are promising new advances in treatment for those patients unsuitable for surgery, although outcomes remain less favourable.Abstract. Lung cancer-related morbidity has a significant impact on the health economy with a 5-year survival rate of 7-9%. Promising early results have been reported in the use of CT screening to reduce mortality. Significant advances have developed in diagnostic imaging with the ever increasing use of positron emission tomography-CT. Nonsurgical invasive sampling methods have been introduced including the use of endoscopic ultrasound-guided needle aspiration. This has been accompanied by advances in surgical techniques, radiotherapy regimes and chemotherapeutic agents. Treatment with curative intent has also increased the role of follow-up imaging, for which regimes are variable between centres and countries. This article aims to review the current evidence with regard to screening, diagnosis, treatment and follow-up.

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How I Do It

Cited by 40 publications

References 70 publications

Cryoablation of cardiophrenic angle lymph node metastases: a case report

Cryoablation of cardiophrenic angle lymph node metastases: a case report

Cryoablation of lung malignancies recurring close to surgical clips following surgery: Report of three cases

Lung cancer: from screening to post-radical treatment

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