How I treat chronic lymphocytic leukemia in older patients

Idelalisib-related pneumonitis

“…Herein, we report for the first time the clinical features of idelalisib-related pneumonitis. The median age of our patients was 72 years, similarly to the median age of patients who are diagnosed with CLL [5]. Respiratory symptoms, including cough, dyspnoea and pneumonia, together with digestive symptoms, were the most frequent adverse events reported in previously conducted clinical trials evaluating the efficacy of idelalisib.…”

“…High-flow nasal cannula oxygen therapy (HFNC) has emerged as a technique for noninvasive respiratory management of hypoxaemic patients [4]. In patients with acute respiratory failure (ARF), its beneficial effects have been shown in various populations [5], and its effectiveness and superiority over NPPV and conventional oxygenation recently demonstrated [6]. Its use has also been described during bronchoscopy in non-hypoxaemic [7] and in hypoxaemic patients in comparison with NPPV [8].…”

Virtual Screening of Adenylate Kinase 3 Inhibitors Employing Pharmacophoric Model, Molecular Docking, and Molecular Dynamics Simulations as Potential Therapeutic Target in Chronic Lymphocytic Leukemia

“…CLL is the most common form of lymphoid malignancies in adults and is characterized by the progressive accumulation of small mature B cells in the peripheral blood and lymphoid organs. Conventional therapeutic options for CLL patients include chemoimmunotherapy, alkylating agents, and purine analogs [5]. High-risk patients are often resistant to first-line treatments, and therapeutic options for them include a tyrosine kinase inhibitor, ibrutinib or Bcl-2 inhibitor, and venetoclax [6,7].…”