How I treat heparin-induced thrombocytopenia and thrombosis

HIT BY HEPARIN: A Rare Case of Late Onset Heparin Induced Thrombocytopenia

“…The neo antigen induces the production of IgG antibodies which bind to the heparin-PF4 structure to form a heaprin-PF4-antibody complex. The complex can bind Fc receptors on the surface of platelets, neutrophils and monocytes and not only activate these cells but also lead to thrombin generation / release which ultimately leads to hypercoagulability, thrombosis and thrombocytopenia [2].…”

Heparin-induced thrombocytopenia

“…HIT atveju varfarino buvo skiriama iškart nutraukus gydymą heparinu (2,7,8,15,19,22,23). Pasirodė, kad tuomet jis gali sukelti galūnių, ypač kojų (jei kojų venose yra trombų) veninę gangreną (angl.…”

“…Danaparoidas (orgaran) (1,2,7,8,10,11,19,23) -heparinoidas, išgaunamas iš kiaulių žarnyno gleivinės. Jo natrio druska -tai trijų glikozaminoglikanų mišinys iš heparano sulfato (84 proc.…”

“…Bivalirudinas (angiomax) (4,11,19,23,25) -pats naujausias tiesioginis trombino inhibitorius, 20 aminorūgščių polipeptidas. Jis yra fragmento hirugeno, išskirto iš hirudino, analogas.…”

Heparin‐induced thrombocytopenia presenting with thrombosis of multiple saphenous vein grafts and myocardial infarction

“…The diagnosis of HIT is suspected clinically in patients who develop thrombocytopenia with or without thrombosis after heparin or low molecular weight heparin exposure. HIT is frequently confirmed by immunologic tests like enzyme-linked immunosorbent assay (ELISA) or functional tests like serotonin-release assay (SRA) [4].…”