How image‐guided core needle biopsies altered the treatment of breast disease: Challenges accepted and opportunities taken

Lester, Susan C.

doi:10.1111/tbj.13862

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…injection of MCMV peptide epitopes induces long-term protection against secondary challenge (i.e., the TC-1 model). In addition to superficial tumors such as melanoma, the recent advances in image-guided biopsy permit the application of intratumoral therapies to tumors located deeper in tissues (e.g., breast, pancreas, prostate) ( 58 , 59 ).…”

Section: Discussionmentioning

confidence: 99%

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors

Çuburu

Bialkowski

Pontejo

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Tumor infiltration by T cells profoundly affects cancer progression and responses to immunotherapy. However, the tumor immunosuppressive microenvironment can impair the induction, trafficking, and local activity of antitumor T cells. Here, we investigated whether intratumoral injection of virus-derived peptide epitopes could activate preexisting antiviral T cell responses locally and promote antitumor responses or antigen spreading. We focused on a mouse model of cytomegalovirus (CMV), a highly prevalent human infection that induces vigorous and durable T cell responses. Mice persistently infected with murine CMV (MCMV) were challenged with lung (TC-1), colon (MC-38), or melanoma (B16-F10) tumor cells. Intratumoral injection of MCMV-derived T cell epitopes triggered in situ and systemic expansion of their cognate, MCMV-specific CD4 + or CD8 + T cells. The MCMV CD8 + T cell epitopes injected alone provoked arrest of tumor growth and some durable remissions. Intratumoral injection of MCMV CD4 + T cell epitopes with polyinosinic acid:polycytidylic acid (pI:C) preferentially elicited tumor antigen–specific CD8 + T cells, promoted tumor clearance, and conferred long-term protection against tumor rechallenge. Notably, secondary proliferation of MCMV-specific CD8 + T cells correlated with better tumor control. Importantly, intratumoral injection of MCMV-derived CD8 + T cell–peptide epitopes alone or CD4 + T cell–peptide epitopes with pI:C induced potent adaptive and innate immune activation of the tumor microenvironment. Thus, CMV-derived peptide epitopes, delivered intratumorally, act as cytotoxic and immunotherapeutic agents to promote immediate tumor control and long-term antitumor immunity that could be used as a stand-alone therapy. The tumor antigen–agnostic nature of this approach makes it applicable across a broad range of solid tumors regardless of their origin.

show abstract

Section: Discussionmentioning

confidence: 99%

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors

Çuburu

Bialkowski

Pontejo

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Image-guided biopsy, when available and feasible, adds the benefit of targeted biopsy of suspicious lesions, detects multifocal and multicentric lesions, and targets solid suspicious regions in heterogeneous and cystic tumours, thus reducing the risk of false negative biopsies. Blind or clinical core biopsies have a role, especially in the context of clinically suspicious lesions that are imaging occult, when the clinical and radiological examinations are discordant [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Clinically guided core biopsy and cutaneous punch biopsy in the evaluation of breast lesions: a necessary test or an obsolete skill?

et al. 2022

View full text Add to dashboard Cite

Objective The vast majority of breast cancers are diagnosed via image-guided procedures yet despite significant advances, imaging does not identify all breast malignancies. Clinically suspicious breast lesions with normal breast imaging remain a cause for concern. The aim of this study is to determine the diagnostic value of clinical core and cutaneous punch biopsies in the diagnosis of breast malignancy in clinically suspicious lesions with normal breast imaging. Methods All patients with suspicious clinical breast findings and normal imaging who underwent a clinical core and/or cutaneous punch biopsy from 2012 to 2019 were reviewed retrospectively. Patients with subsequent breast malignant diagnosis were analysed. Results A total of 283 biopsies (166 clinical core, 117 cutaneous punch) performed over the 7-year period were included in the analysis. A total of 263/283 (93%) yielded a benign outcome. A total of 2/283 (0.7%) yielded B3 lesions (probably benign). These lesions were benign on final surgical excision. A total of 18/283 (6.3%) yielded a malignant histopathology. Sixteen out of 18 were cutaneous punch biopsies, and 2/18 were clinical core biopsies. A total of 14/18 patients presented with nipple changes, while 4/18 had a palpable area of concern. Histopathological analysis demonstrated Paget’s disease of the nipple in 8/18, invasive carcinoma in 9/18 out of which two represented a recurrence of breast malignancy. Cutaneous squamous cell carcinoma was diagnosed in 1/18. Conclusion Clinical core and cutaneous punch biopsies remain a valuable tool in the diagnosis of breast cancer particularly in the management of clinically suspicious radiographically occult malignancies.

show abstract

Essential Components of a Successful Breast Core Needle Biopsy Program: Imaging Modalities, Sampling Techniques, Specimen Processing, Radiologic/Pathologic Correlation, and Appropriate Follow-Up

Denison

Lester²

2022

A Comprehensive Guide to Core Needle Biopsies of the Breast

View full text Add to dashboard Cite

How image‐guided core needle biopsies altered the treatment of breast disease: Challenges accepted and opportunities taken

Cited by 3 publications

References 21 publications

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors

Clinically guided core biopsy and cutaneous punch biopsy in the evaluation of breast lesions: a necessary test or an obsolete skill?

Essential Components of a Successful Breast Core Needle Biopsy Program: Imaging Modalities, Sampling Techniques, Specimen Processing, Radiologic/Pathologic Correlation, and Appropriate Follow-Up

Contact Info

Product

Resources

About