How Is Hodgkin Lymphoma in Pregnancy Best Treated?

Abstract

A 26-year-old woman who is 22 weeks into her first pregnancy presents with a new diagnosis of Hodgkin lymphoma (HL). In preparing for her treatment you wonder about the safety and efficacy of chemotherapy during pregnancy.A comprehensive literature review was conducted to evaluate the safety and effectiveness of chemotherapy for pregnant patients with HL. Medline

Hodgkin Disease and Pregnancy - A Case Report

“…Also infants born to mothers with HB had a higher incidence of prematurety and intrauterine retardation of growth and development. There are no data on the metastasis of HD in the placenta or fetus [8].…”

Management of immune-mediated cytopenias in pregnancy

“…However, favorable pregnancy outcomes have been reported with their use in the second and third trimesters in the patients with malignancies [27]. Experience with thiopurines in pregnancy is primarily in patients with inflammatory bowel disease but has not been reported in pregnant patients with ITP [28].…”

Hämatologische Neoplasien in der Schwangerschaft

“…Allerdings ist eine intensive Chemotherapie einschließlich Dacarbazin für Hodgkin-Lymphome entscheidend; eine unzureichende Behandlung kann das Risiko für ein Rezidiv deutlich erhöhen. Daher sollte ABVD als Therapie der ersten Wahl gelten, auch wenn die Evidenz für eine Chemotherapieempfehlung bei schwangeren Patientinnen dürftig ist [4]. Das Ansprechen und die Überlebens-raten sind mit denen nichtschwangerer Patientinnen vergleichbar [1].…”